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TB VACCINES WORKING GROUP

TB VACCINES WORKING GROUP. Douglas Young. Stop TB Partners’ Forum New Delhi March 2004. BCG VACCINE. live attenuated Mycobacterium bovis bacillus of Calmette and Guerin. BCG provides some useful level of protection against childhood TB.

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TB VACCINES WORKING GROUP

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  1. TB VACCINES WORKING GROUP Douglas Young Stop TB Partners’ Forum New Delhi March 2004

  2. BCG VACCINE live attenuated Mycobacterium bovis bacillus of Calmette and Guerin

  3. BCG provides some useful level of protection against childhood TB BCG provides little or no protection against adult pulmonary TB

  4. immune response reactivation reinfection X disease 1° disease disease BCG infection Primary tuberculosis, post-primary tuberculosis, and BCG bacterial load few weeks months/years/decades

  5. disease 1. prevent establishment of initial infection 2. prevent progression from latent infection to active disease Profile of improved tuberculosis vaccines disease disease bacterial load

  6. attenuated mycobacteria (25) recombinant vaccines (29) DNA vaccines (43) purified proteins (114) preclinical screening of 268 TB vaccine candidates Ian Orme, Colorado State University

  7. two new TB vaccine candidates are now in phase I clinical trials

  8. Vaccine Expectations

  9. partially protective vaccine + improved diagnostics + new drugs • clinical trials: opportunity for capacity strengthening

  10. Vaccine Working Group Activities provide an international forum for discussion of vaccine issues • economic case for TB vaccines • standardised regulatory requirements • trial site directory • immunological assays • BCG • interactive website

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