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Improving Field-Induced Magnetic Nanoparticle Drug Delivery

Improving Field-Induced Magnetic Nanoparticle Drug Delivery. BME 273 Group 15 Team Leader : Ashwath Jayagopal (BME, EE, MATH) Members : Sanjay Athavale (BME) and Amit Parikh (BME)

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Improving Field-Induced Magnetic Nanoparticle Drug Delivery

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  1. Improving Field-Induced Magnetic NanoparticleDrug Delivery BME 273 Group 15 Team Leader : Ashwath Jayagopal (BME, EE, MATH) Members : Sanjay Athavale (BME) and Amit Parikh (BME) Advisor : Dr. Dennis Hallahan, Chairman of Radiation Oncology and Professor of Biomedical Engineering and Radiation Oncology, Vanderbilt University

  2. There is a strong rationale for magnetic nanoparticle related design projects • Drug Delivery • Improving noninvasive medical imaging (MRI) • Microsensors • Gene Therapy

  3. The properties of magnetic nanoparticles can be varied to make a specific recipe • Diameter • Coating • Chemical modifications • Absorption, tracer strength Gold-coated iron nanoparticles exhibit different absorption spectrums for use in medical imaging (Chinese Academy of Sciences, 2000)

  4. Our project aims to improve the processes of magnetic nanoparticle drug delivery • There are several primary concepts involved: • Magnetic nanoparticle properties (Ga. Tech) • External field induction design • Heating and irradiation • Chemical enhancements • Goal : A process that results in homogenous and local drug distribution in a variety of tumors

  5. We seek to combine several aspects in order to enhance magnetofection in tumors • Feasible: • Microelectromagnet • Current loop, multi-layered wire matrix • Heating and irradiation processes • Not possible: • Alteration of nanoparticle properties • Chemical purification and coating

  6. There are several obstacles that demand attention • Nanoparticle Aggregation • Tumor Permeability • Drug Delivery location and duration • Resources • Controllable? • Sizing (immune system detection, circulation stability) • Low energy barrier (for rapid magnetic state changes)

  7. Current Status • Certification, have met with all relevant VUMC personnel • Have requested magnetic nanoparticle sample sets of various properties • Consulting Dr. Hallahan and other personnel on possibility of designing a microelectromagnet for our purpose • Scheduled to observe magnetic nanoparticle mobility experiments

  8. Future Objectives • Conduct experiments on mice tumors using nanoparticles (otherwise using tumor models), once samples obtained • Open consultation with nanotechnology group at Georgia Tech • Begin design of a microelectromagnet “trap” to achieve homogenous nanoparticle distribution • Continue consultation with all involved personnel

  9. Current Individual Responsibilities Ashwath : team leader, directly responsible for reporting progress to advisor and related personnel. Involved in design and contacts with related research companies. Sanjay : Involved in research related to magnetic nanoparticle drug delivery. Amit : Patent searching, researching possible methods of trapping nanoparticles to achieve a desired distribution.

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