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Materials and methods

Materials and methods. Design Open-label, randomized trial, February 2010 to May 2011, avoiding the summer period Participants recruited from a primary care centre in Sweden , serving a population with a high proportion of non-European residents Inclusion criteria

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Materials and methods

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  1. Materials and methods • Design • Open-label, randomized trial, February 2010 to May 2011, avoiding the summer period • Participants • recruited from a primary care centre in Sweden, serving a population with a high proportion of non-European residents • Inclusion criteria • age 15 years or above and vitamin D deficiency 25(OH)D3 less than 25 nmol /L • Exclusion criteria • light-sensitive skin • ongoing treatment with vitamin D supplementation • sunny holidays • intake of photosensitive medicine during the study period.

  2. UVB • The average starting dose was 0.36 J • increments were about 15% every second treatment session • the average maximal (final) dose was 1.20 J. • The mean cumulative dose was 9.0 J /cm2

  3. Results • Significantly greater increase in 25(OH)D3 levels in the NB-UVB treated group compared with the tablet-treated group after 6 weeks of treatment (P = 0.02) • in the NB-UVB treated group The 25(OH)D3 levels (mean ± SD) increased from 19.2 ± 6 nmol/L to 75 ± 16.8 nmol/L vs. 23.3 ±4.4 nmol/L to 60.6 ± 16.7 nmol /L in the oral vitamin D3 treated group

  4. Results • No significant difference regarding PTH, calcium, albumin or HbA1c levels. • Asignificant decrease in PTH • A significant increase in calcium levels

  5. Limitations • lack of compliance among the group who took vitamin D3 supplements • high dropout number • primarily non-European immigrants

  6. Conclusion • exposure to a small dose of full body NB-UVB radiation three times a week is more efficient in raising vitamin D levels than prescription of a daily oral intake of 1600 IU vitamin D3

  7. Race ?Skin type ?

  8. Suscreen ?

  9. Winter vs summer

  10. NB UVB vs BB UVB ?

  11. Diet ?

  12. Screening ?

  13. Deficiency ?

  14. -Vitamin D deficiency is defined as a 25(OH)D below 20 ng/ml (50 nmol/liter)- Vitamin D insufficiency is defined as a 25(OH)D of 21–29 ng/ml

  15. Daily requirement ?

  16. Treatment

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