1 / 4

Supplementary Table 1; Wong, Wang, Smith, Reddy and Chen

lukas
Download Presentation

Supplementary Table 1; Wong, Wang, Smith, Reddy and Chen

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript


  1. Article Title: AKT-aro and HER2-aro, models for de novo resistance to aromatase inhibitors; molecular characterization and inhibitor response studies Journal Name: Breast Cancer Research and TreatmentAuthor Names and Affiliations: Cynthie Wong1, Xin Wang1, David Smith2, Kaladhar Reddy3 and Shiuan Chen11Division of Tumor Cell Biology, 2Department of Information Sciences, Beckman Research Institute of the City of Hope, Duarte, CA 91010, 3Department of Pathology, Wayne State University, Detroit, MI 48201Corresponding author email address: schen@coh.org

  2. Supplementary Table 1; Wong, Wang, Smith, Reddy and Chen

  3. 48 hr 72 hr 24 hr 72 hr 48 hr 24 hr Supplementary Figure 1; Wong, Wang, Smith, Reddy and Chen B A AKT-aro HER2-aro Supplementary Figure 1. 17-DMAG induces G2 phase arrest. Cells were treated with either DMSO or 100 nM 17-DMAG for 24, 48, or 72 h. a) AKT-aro and b) HER2-aro cells were stained with propidium iodide and analyzed by flow cytometry.

  4. Supplementary Figure 2; Wong, Wang, Smith, Reddy and Chen Supplementary Figure 2. 17-DMAG suppresses ER activity. The pGL3-(ERE)3 reporter plasmid was transiently transfected into MCF-7aro, AKT-aro and HER2-aro cell lines. Cell lines were treated with either DMSO or 100 nM 17-DMAG, in addition to 1 nM E2 for 48 hours. Data (mean ± SD) is representative of 3 independent experiments performed in triplicate.

More Related