State Research Center of Russian Federation Federal State Unitary Enterprise

1. State Research Center of Russian Federation Federal State Unitary Enterprise «Karpov Institute of Physical Chemistry» Obninsk Branch

2. Branch of Federal State Unitary Enterprise «Karpov Institute of Physical Chemistry» Address: 109 km, Kievskoye Shosse, Obninsk Kaluga Region Telephone: (48439)6-39-32, 7-47-50 Fax: (48439)6-39-11 E-mail: fci@KarpovIPC.ru Location: 109 km south-west of Moscow Area: more than 70 haLeadingCenter of radiation Chemistry in Russia

3. Branch of Federal State Unitary Enterprise «Karpov Institute of Physical Chemistry» Areas of scientific research and development: - high-energy chemistry; - radiochemistry; - nuclear chemistry and physics; - development of new radiopharmaceuticals; - chemistry of high-molecular weight compounds; - solid state physics; - radiation-chemical technologies; - radiation and space materials technology; - neutron diffraction investigation and dynamics of different class crystals.

4. Branch of Federal State Unitary Enterprise «Karpov Institute of Physical Chemistry» Up-to-date experimental and technological facilities, including: • nuclear reactor WWR-c; - electron beam accelerators; - powerful radionuclide sources of gamma radiation;- wide range of technological facilities; • - testing and research units to investigate organic and inorganic materials in the frames of radiation and space materials technology projects; • experimental-production shop.

5. Nuclear-chemical technologies

6. Branch of Federal State Unitary Enterprise • «Karpov Institute of Physical Chemistry» • Leading producer and supplier of radiopharmaceuticals and technetium-99m generators in Russia. • Karpov’s radionuclide and radiopharmaceutical products are delivered to all Russian clinics. • Development and production of radiopharmaceuticals for diagnostics and therapy are realized as an integrated production cycle

7. Nuclear reactor or cyclotron-based production of radionuclides Recovery of radionuclides Generator Synthesis of carrier-molecules Clinic Labeling Preparation of reagent kits Preparation of radiopharmaceuticals . Production of radiopharmaceuticals • .

8. Experimental and production facilities Reactor WWR-c Power – 10 MW Fluence – 5× 1013 n/cm2·s Number of experimental channels – 31, including 9 horizontal Number of hot cells – 9, each handling 10000 g-equ. Ra Number of heavy chemical boxes - 5

9. Currently produced radiopharmaceuticals

10. Currently produced radiopharmaceuticals

11. Technetium-99m generator GMP production line for loading Tc-99m generators is under construction The design makes it possible - to decrease the number of procedures, which ensure operation condition of the generator; • to use light biological shielding; • to install a bactericide filter to obtain aseptic eluate of sodium pertechnetate.

12. Radiopharmaceuticals being developed Diagnostics of myocardial infarction For diagnostics of myocardial preinfarction condition based on fat phenylmethylpentadecanoic acid labeled with 123I 99mTcN-DBODC5-heterocomplex composed of PNP5 and dithiocarbamate ligand Thermoselfcollapsing therapeutical radiopharmaceutical Х = 153Sm, 188Re , 90Y, 117mSn

13. Items produced by radiation-chemical technology Nuclear-doped semiconductor materials (silicon, gallium arsenide, etc. for power electronics) Radiation-modified minerals (topazes, etc.)

14. Pilot projects: • to build up a facility for Technetium-99m generator loading in accordance withGMP requirements; • to build-up an up-to-date facility for radiochemical production of radionuclides and radiopharmaceuticals (investment project developed); • to develop a technology and build up a facility for production of alpha-emitters actinium-225 and radium-223; • to launch molybdenum-99 production from low-enriched uranium targets.

15. RADIATION- CHEMICAL TECHNOLOGIES

16. Radiation-chemical technologies developed by Karpov Institute • curing of paint coatings on the surface of wooden, metallic and gypsum products; • modification of rubber products(tires, etc. ); • production of composite materials (binders and prepregsfor further manufacturing high-strength and heat-resistant products); • modification of polyolefins(production of foamed polyethylene materials and products, hot water supply and heating pipes, gas distribution piping, heat –shrinkable tapes for electric insulation); • sterilization of medical products, drugs, herbal raw material; • synthesis of polymer latexesfor wall-paper and tanning industry,gel production for perfumery and pharmaceuticals;

17. Radiation-chemical technologies developed by Karpov Institute • monomer grafting onto polymer products (to obtain adhesion-bonding surfaces and separation materials for chemical current sources); • processing of minerals and microelectronic products(to obtain marketable semi-precious stones and to increase microchip characteristics); • destruction of Teflon; • radiation-chemical modification of Teflon; • production of porous filters (to purify water, air, fuel, aggressive liquids)

18. Electron beam accelerators

19. Experimental and production facilities УЭЛР-10-10-Т-80 in a trench Locally-shielded accelerator “Electron-3M”

20. Technological facility for PE cross-linking. Production of foamed polyethylene and heat-shrinkable insulation tape.

21. Technical characteristics of Co-60 γ-facilities, total activity 1490 kCi

22. Items produced by radiation-chemical technology Products made from foamed polyethylene sheets

23. Items produced by radiation-chemical technology Heat-resistant polyethylene pipes Radiation-modified heat-shrinkable items

24. Items produced by radiation-chemical technology Polyethylene filters To purify: • drinking water, • beverages, • paints and resins, • photoemulsions, • water and reagents for microelectronics, • magnetic paint, • lubricants and cooling liquids. Pore size, m1 - 100 Total porosity, % 50-55 Efficiency of water purification from 1 m particles, %99.55 Tmax, OC 100

25. Branch of Federal State Unitary Enterprise «Karpov Institute of Physical Chemistry» • PILOT PROJECTS • center of radiation sterilization and decontamination of medical wastes; • specialized facility for radiation modification of polytetrafluoroethylene

26. Thank you for your attention