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MODULE 5

MODULE 5 . Pharmaceutics. 1. RA 8203 was signed into law on:. September 4, 1996 September 13, 1988 October 4, 1996 September 13, 1986 September 4, 1992. 2. A complete pharmacy internship program based on RA 5921 article III section 18c shall consist of at least:. 480 hours 960 hours

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MODULE 5

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  1. MODULE 5 Pharmaceutics

  2. 1. RA 8203 was signed into law on: • September 4, 1996 • September 13, 1988 • October 4, 1996 • September 13, 1986 • September 4, 1992

  3. 2. A complete pharmacy internship program based on RA 5921 article III section 18c shall consist of at least: • 480 hours • 960 hours • 160 hours • 980 hours • 940 hours

  4. 3. This means a method of secret writing that substitutes other letters or characters for the letter intended, or transpose the letter after arranging them in blocks or squares. • Code • Cipher • Secret Keys • Substitution • NOTA CODE – system of words or other systems arbitrarilyused to present words SECRET KEYS – characteristic styles or symbols kept from the knowledge of others or disclosed confidentially to only one or a few

  5. 4. RA 3720 is also known as: • Pharmacy Law • Consumer Act of the Philippines • Food, Drugs, Cosmetics and Devices Act • Senior Citizens Act • Special Law on Counterfeit Drugs

  6. 5. Amount of morphine subject to life imprisonment to death penalty and a fine of 500,000 pesos to 10M pesos: • 500g • 50g • 10g • 1g • 20g MARIJUANA – 500 g SHABU – 50 g

  7. 6. Ratio of the weight of a substance to the weight of an equal volume of another substance taken as a standard. • Density • Specific gravity • Optical Activity • Refractive index

  8. 7. Compute for the specific gravity of potassium dichromate (K2Cr2O7) if its weight t in air =5.76g and its weight in oil 3.08g. The sp.gr of the oil is 0.86. • 1.86 • 1.85 • 1.87 • 1.88 Sp. Gr = [ wt. in air/ (wt. in air – wt. in oil)] x sp. Gr of oil

  9. 8. Floatation method for the determination of specific gravity is based on whose scientist’s principle? • Aristotle • Newton • Einstein • Archimedes

  10. 9. A type of hydrometer which is used to determine the alcohol strength of any liquid containing only alcohol and water. • Falle’s hydrometer • Baume hydrometer • Thalles’ hydrometer • Nicholson’s hydrometer Baume hydrometer – used for liquid heavier or lighter than water Nicholson’s hydrometer – type of hydrometer with constant depth of immersion but variable weight. Other examples of such will be Fahrenheit hydrometer, Lovi’s bead

  11. 10. A method of expressing concentration where in concentration is directly proportional to the moles of solute and inversely proportional to the volume of solution • %w/v • %w/w • M • m M – symbol for MOLARITY m – symbol for MOLALITY

  12. 11. The pH value is calculated mathematically as the: A. Log of the hydroxyl ion (OH-) concentration. B. Negative log of the OH- concentration. C. Log of the hydrogen ion (H+) concentration. D. Negative log of the H+ concentration. E. Ratio of H+ /OH- concentration.

  13. 12. Which property is classified as colligative? A. Solubility of a solute B. Osmotic pressure C. Hydrogen ion (H+) concentration D. Dissociation of a solute E. Miscibility of the liquids

  14. 13. Which equation is used to predict the stability of a drug product at room temperature from experiments at accelerated temperatures? A. Stokes equation B. Young equation C. Arrhenius equation D. Michaelis-Menten equation E. Hixson-Crowel l equation

  15. 14. The pH of a buffer system can be calculated with the: A. Noyes-Whitney equation B. Henderson-Hasselbalch equation C. Michaelis-Menten equation D. Young equation E. Stokes equation

  16. 15. Based on the relation between the degree of ionization and the solubility of a weak acid, the drug aspirin (pKa 3.49) will be most soluble at A. pH 1.0 B. pH 2.0 C. pH 3.0 D. pH 4.0 E. pH 6.0

  17. 16. Normally, how many % of water is contained in a hard gelatin capsule? • 8-10 • 12-16 • 20-25 • 2-5 • 5-10

  18. 17. The largest size of hard, empty gelatin capsule that can be swallowed is: • 00 • 000 • 1 • 5 • 0 The smaller the number the bigger the capsule

  19. 18. This chemical agent is used to render the capsule opaque • Titanium dioxide • Sorbitol • Magnesium oxide • Silica • Lactose

  20. 19. This is a method of preparing tablets in which the powder mixture is compacted in large pieces and subsequently broken down or sized into granules • Wet granulation • Dry granulation • Direct compression • In dry granulation, the powder mixture is slugged or compressed into large flat tablets or pellets of about 1 inch in diameter. The slugs are broken up by hand or by the mill and pass through a screen.

  21. 20. The following statement/s is/are true for wet granulation method: • Liquid binder is added to the powder mixture to facilitate the adhesion of the powder particles • Over-wetting of the powder can result in granules that are too soft for proper tableting and under wetting can result in tablets that are too hard and tend to crumble • Granules may be dried in thermostatically controlled ovens which constantly record the time, temperature and humidity

  22. 21. Amount of shabu subject to life imprisonment to death penalty and a fine of 500,000 pesos to 10M pesos: • 10g • 20g • 50g • 100g • 5000g

  23. 22. An ordinary prescription shall be preserved for a period of_______. • 5 years • 1 year • 3 years • 2 years 5 years – POISON 1 year – DANGEROUS DRUGS

  24. 23. When the generic name and brand name are NOT legible, this is a/an___________ prescription. • Violative • Erroneous • Impossible • NOTA • Impossible prescription: • Only the generic name is written but is NOT legible • Generic name does NOT correspond with the brand name • Both generic and brand name are NOT legible • Drug product prescribed is NOT registered with the BFAD

  25. 24. Supplies or medicines to be given to senior citizen should not exceed • One day supply • One week supply • One month supply • One year supply

  26. 25. Most biological are stored at this temperature: • 2 – 8°F • 12 – 8°F • 2 – 8°C • 12 – 8°C

  27. 26. LAL stands for: • Limulus Antibiotic Lysate • Lyophilized Antibiotic Lysate • Limulus AmoebocyteLysate • Lyophilized AmoebocyteLysate

  28. 27. The normal moisture content of hard gelatine capsules: • 2 -5% • 12 – 16% • 20 – 24% • 25 – 30%

  29. 28. When the generic name is not written in a prescription, this is a case of: • Violative prescription • Erroneous prescription • Impossible prescription • NOTA • Violative prescription: • Generic name is NOT written • Generic name is NOT legible and brand name is legible • Brand name is INDICATED and instructions added (e.g. “NO SUBSTITUTION”)

  30. 29. “Rule of Thumb” is the principle applied for testing: • Ampules • Implantations • Vials • Compressed Tablets

  31. 30. It refers to the release or movement of the components of the plastic container into the contents: • Sorption • Absorption • Adsorption • Leaching Sorption and Absorption – refers to the binding of drug molecules to the polymer material of the plastic container

  32. 31. It states that vapor pressure of component is equal to its mole fraction times vapor pressure in the pure state at that same temperature. • Raoult’s law • Henry’s law • Charles’ law • Fick’s law

  33. 32. Which of the following is not a colligative property? • Boiling point elevation • Freezing point depression • Vapor pressure elevation • Osmotic pressure - vapor pressure LOWERING

  34. 33. Dissociation constant for substances that dissociates into 5 ions • 4.2 • 1.8 • 3.4 • 2.6 B – 2 ions C – 4 ions D – 3 ions

  35. 34. Compute for the E value of PapaverinesulfateHCl (MW 376) which is a 2 ion electrolyte dissociating 80% in a given concentration. • 0.1554 • 0.1555 • 0.1556 • 0.1557 E= (MW NaCl/iNaCl) x (i substance/ MW substance) E= (58.5/1.8) x (1.8/376) E= 0.15558 /0.1556

  36. 35. A simplication of the White-Vincent method where the weight of the drug is fixed in 0.3g for one fluidounce of a 1% solution. • Modified White-Vincent method • Scowle’s method • Sprowl’s method • Cryoscopic method

  37. 36. Dosage form made by compression or molding • Tablets • Capsule • Syrup • Suspension

  38. 37. A characteristic of material for compression which describes the way the material flow thru the hopper • Fluidity • Compressibility • Dryness • Particle size

  39. 38. Spray drug lactose when used in direct compression can hold how many % of active ingredient? • 18% • 15% • 20% • 30% It can hold 20-25% of the active ingredient

  40. 39. Which of the following is not a glidant? • CAB-O-SIL • DL-Leucine • Syloid • Talc - It is solely used as an anti-adherent. (A), (C), & (D) are used as both glidant and anti-adherent. Glidants - improve flow property. Anti-adherent - prevents sticking & picking.

  41. 40. Clays are limitedly used for what type of tablets due to its tendency to cause unwanted appearance? • White tablets • Colored tablets • Both • NOTA

  42. 41. Which solution is used as an astringent? A. Strong iodine solution USP B. Aluminum acetate topical solution USP C. Acetic acid NF D. Aromatic ammonia spirit USP E. Benzalkonium chloride solution NF Aluminum acetate - used as antiperspirants and wet dressings for contact dermatitis Strong iodine and Benzalkonium chloride – topical antibacterial solutions Acetic acid - acidifier Aromatic ammonia spirit – respiratory stimulant

  43. 42. The particle size of the dispersed solid in a suspension is usually greater than A. 0.5 μm B. 0.4 μm C. 0.3 μm D. 0.2 μm E. 0.1 μm A suspension is a two-phase system that consists of a finely powdered solid dispersed in a liquid vehicle

  44. 43. In the extemporaneous preparation of a suspension, levigation is used to: A. reduce the zeta potential B. avoid bacterial growth C. reduce particle size D. enhance viscosity E. reduce viscosity Levigationis the process of blending and grinding a substance to separate the particles, reduce their size, and form a paste.

  45. 44. Which compound is a natural emulsifying agent? A. acacia B. lactose C. polysorbate 20 D. polysorbate 80 E. sorbitanmonopalmitate

  46. 45. Rectal suppositories intended for adult use usually weigh approximately A. 1 g B. 2 g C. 3 g D. 4 g E. 5 g

  47. 46. In the fusion method of making cocoa butter suppositories, which substance is most likely to be used to lubricate the mold? A. Mineral oil B. Propylene glycol C. Cetyl alcohol D. Stearic acid E. Magnesium silicate

  48. 47. A very fine powdered chemical is defined as one that A. completely passes through a #80 sieve. B. completely passes through a #120 sieve. C. completely passes through a #20 sieve. D. passes through a #60 sieve and not more than 40% through a #100 sieve. E. passes through a #40 sieve and not more than 60% through a #60 sieve.

  49. 48. Which technique is typically used to mill camphor? A. trituration B. levigation C. pulverization by intervention D. geometric dilution E. attrition Pulverization by intervention is the milling technique that is used for drug substances that are gummy and tend to re-agglomerate or resist grinding (e.g. camphor , iodine)

  50. 49. The dispensing pharmacist usually blends potent powders with a large amount of diluent by A. spatulation B. sifting C. trituration D. geometric dilution E. levigation

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