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Histo-blood group antigens as allo- and/or autoantigens

Histo-blood group antigens as allo- and/or autoantigens. Nydegger, U.E. and Flegel, W.A. University of Bern, Switzerland and University of Ulm, Germany info@immune-complex.ch - www.immune-complex.ch 4th International Congress Autoimmunity Budapest 2004.

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Histo-blood group antigens as allo- and/or autoantigens

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  1. Histo-blood group antigens as allo- and/or autoantigens Nydegger, U.E. and Flegel, W.A. University of Bern, Switzerland and University of Ulm, Germany info@immune-complex.ch - www.immune-complex.ch 4th International Congress Autoimmunity Budapest 2004

  2. Blood group antigens assigned to systems Slide courtesy of D. Anstee 1997

  3. World Wide Web sites for Blood Group Antigens • http://www.bioc.aecom.yu.edu/bgmut/index.htm • http://www.uni-ulm.de/~wflegel/RH/ • http://jove.prohosting.com/~scarfex/blood/groups.html Nydegger UE, Flegel WA 2004

  4. I/i P Kell Lewis MN Cold agglutinins Cold agglutinins Donath-Landsteiner antibodies Warm-reactive autoantibodies Helicobacter pylori molecular mimicry Treponema pallidum molecular mimicry Blood group antigens as autoantigens Nydegger UE, Flegel WA 2004

  5. Blood groups on the RBC Lutheran ABO Ii Gerbich Knops Diego Yt Duffy MNS Cromer Indian LW Kell Rh Slide courtesy of E. Sjoberg-Wester

  6. Lea B type 1 A type 1 H type 1 Leb -L-Fuc(1-2) ß-D-Gal(1-3)[-L-Fuc(1-4)]ß-D-GlcNAc ß-D-Gal(1-3)[-L-Fuc(1-4)]ß-D-GlcNAc -D-Gal(1-3) [-L-Fuc(1-2)] ß-D-Gal(1-3)ß-D-GlcNAc -D-GalNAc(1-3) [-L-Fuc(1-2)] ß-D-Gal(1-3)ß-D-GlcNAc -L-Fuc(1-2) ß-D-Gal(1-3)ß-D-GlcNAc Chemical basisof the ABO and Lewis blood group system Type 1 Precursur Substance Nydegger UE, Flegel WA 2004 ß-D-Gal(1-3)ß-D-GlcNAc

  7. Disappearance of B and appearance of H Antigen Koestner et al. Lancet 363(2004)1523 Months post transplant Controls 36 30 14 2 B type O type O type Monoclonal antibodies Lectin

  8. ABOI heart allograft: follow up for 44 months post transplant B Antigen Nydegger UE, Flegel WA 2004 H Antigen Post transplant: 12 24 36 44 months

  9. Conclusion • Numerous blood group system antigens • occur not only on red blood cells • but are also expressed on cells of various other tissues • Hence, autoantibodies • known to impinge on red cells • are also reactive for various other tissues • Blood group antigens • might be more frequently involved as tissue autoantigens • and should be more often considered in this context Nydegger UE, Flegel WA 2004

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