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Non-Tumor

A. Analyzing Primary Tumor Growth. 4wks. Randomization at ~200 mm 3 and Treatment Initiation. Analyzing Lung Metastasis. Kras G12D p53 -/- Lung tumors. SC implantation in SCID mice (KPT). 3500. B. C. Vehicle. 6. 3000. Carboplatin. 5. 2500. AOM1. Meant Volume (mm 3 ). 4.

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Non-Tumor

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  1. A Analyzing Primary Tumor Growth 4wks Randomization at ~200 mm3 and Treatment Initiation Analyzing Lung Metastasis KrasG12Dp53-/- Lung tumors SC implantation in SCID mice (KPT) 3500 B C Vehicle 6 3000 Carboplatin 5 2500 AOM1 Meant Volume (mm3) 4 2000 Combination Plasma OPN (ug/ml) 3 1500 2 1000 1 500 0 0 8 13 16 20 23 27 Days Post-Implantation Non-Tumor Tumor Isotype Isotype CD44 β3 αv D KP 100 100 100 100 101 101 101 101 102 102 102 102 103 103 103 103 104 104 104 104 Counts mPBMC αvβ3 CD44

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