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Laboratory – Immunogenicity Biomarkers / Macromolecule PK

Laboratory – Immunogenicity Biomarkers / Macromolecule PK. Veeda CR - Equipment Platforms. Keeping abreast of technology!. Nano-technology “CD” based system Rapid Method Dev. GYROS - GYROLAB. Gyrolab ®. Bioanalytical system for automated protein quantification. Flexible assay format.

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Laboratory – Immunogenicity Biomarkers / Macromolecule PK

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  1. Laboratory – Immunogenicity Biomarkers / Macromolecule PK Veeda CR - Equipment Platforms Keeping abreast of technology! • Nano-technology • “CD” based system • Rapid Method Dev. GYROS - GYROLAB

  2. Gyrolab® Bioanalytical system for automated protein quantification

  3. Flexible assay format Bridging assay Sandwich assay Indirect antibody assay

  4. Immunoassays on Gyrolab Bioaffy

  5. Automatic processing from sample to evaluation Gyrolab Workstation LIF • Samples in 96-well microplates • High sensitivity fluorescence detection • Gyrolab Workstation software Gyrolab Bioaffy • 5 CDs per batch run

  6. 102 101 100 Response 10-1 10-2 10-2 10-1 100 101 102 103 104 Concentration (mg/L) Working ranges for IgG assays - Using Gyrolab Bioaffy 200 & 20HC Gyrolab Bioaffy® 200 Gyrolab Bioaffy® 20 HC HPLC ELISA

  7. Workflow benefits with Gyrolab Bioaffy® • Flexible assay design • Compatible with many assay formats • Automation and integration • Significant reduction in reagent and sample consumption • Reduced ’hands-on’ time and labor cost • Assay development straightforward and easy • Broader analytical range • Reduced matrix effects • Maintained accuracy and precision

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