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Lecture 2 – Introduction to autism research Ilan Dinstein

Lecture 2 – Introduction to autism research Ilan Dinstein. What is the cause of autism?. Dendrites. Cell body. Axon. Neural activity. Modularity. Developmental disorder. Brain development movie. Nature versus nurture Genes or Environment?. Genetics. Control > ASD. DNA sequencing.

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Lecture 2 – Introduction to autism research Ilan Dinstein

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  1. Lecture 2 – Introduction to autism researchIlan Dinstein

  2. What is the cause of autism?

  3. Dendrites Cell body Axon

  4. Neural activity

  5. Modularity

  6. Developmental disorder Brain development movie

  7. Nature versus nurture Genes or Environment?

  8. Genetics Control > ASD

  9. DNA sequencing Control > ASD

  10. Identify meaningful mutation Substitution Control > ASD Deletion Insertion

  11. What is the function of the protein that the gene encodes? Is it involved in neural transmission? Neural development? Synaptic development? Determine the function of the gene Bourgeron 2009

  12. Compare animals with extremely similar genetics except for a specific modification. Create a genetically modified animal model Control > ASD

  13. Perform behavioral experiments Control > ASD Testing social behavior in mice

  14. In vitro electrophysiology Control > ASD

  15. In vivo electrophysiology Control > ASD

  16. Electrical properties of cells & networks Control > ASD

  17. Electrode location Control > ASD

  18. Cellular morphologyand connectivity Control > ASD

  19. Human genetics – SFARI, Autism Speaks Neuroimaging – MRI, fMRI, DTI Electrophysiology – EEG Post mortem What about humans?

  20. Human genetics

  21. Magnetic resonance imaging (MRI)

  22. Anatomy - Separating tissues 1T 2T

  23. Anatomy – Cortical thickness

  24. Anatomy – Cortical folding

  25. Anatomy – white matter Tractography Fiber volume Fiber length

  26. Electroencephalogram - EEG Control > ASD

  27. EEG and epilepsy Control > ASD Epileptiform activity Epileptic seizure Spence, Pediatrics Res 2009

  28. Brain slices: Post mortem studies Control > ASD

  29. Cellular morphology Post mortem studies Control > ASD

  30. Neural numbers and organization Post mortem studies Control > ASD

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