1 / 17

Gluck ME, Geliebter A, Hung J, and Yahav E. Psychosom Med. 2004 Nov-Dec;66(6):876-81 .

Cortisol,Hunger, and Desire to Binge Eat Following a Cold Stress Test in Obese Women with Binge Eating Disorder. Gluck ME, Geliebter A, Hung J, and Yahav E. Psychosom Med. 2004 Nov-Dec;66(6):876-81. Nick Bello ED Journal Club 05-Dec-2008. Introduction. Binge eating disorder (BED)

maite-phelps
Download Presentation

Gluck ME, Geliebter A, Hung J, and Yahav E. Psychosom Med. 2004 Nov-Dec;66(6):876-81 .

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Cortisol,Hunger, and Desire to Binge Eat Following a Cold Stress Test in Obese Women with Binge Eating Disorder Gluck ME, Geliebter A, Hung J, and Yahav E. Psychosom Med. 2004 Nov-Dec;66(6):876-81. Nick Bello ED Journal Club 05-Dec-2008

  2. Introduction • Binge eating disorder (BED) • Frequent and regular intake large amount of food twice a week for 6 months • Sense of “loss of control” over eating • No inappropriate compensatory behaviors • BED is 2% of the nonpatient general community • ~ 30% obese people seeking medical treatment

  3. Introduction (continue) • Stress and binge eating • Stress and negative affect precursors to binge eating • Cortisol is the major hormonal component to stress response. • Exogenous glucocorticoids induce obesity by increasing food intake. • Elevated cortisol levels associated with energy intake in health individuals.

  4. HPA Axis and dexamethasone test (DST)

  5. Cold Pressor Test (CPT) Life, December 1955

  6. Hypothesis • Obese women with BED compared with non-BED • Increase CORT after CPT • More hungry and desire to binge eat after CPT • Less CORT suppression after DST

  7. Methods (Participants) • Obese women (n=38) were recruited by local advertisements • Exclusion Criteria • Significant health problem other than obesity • Unstable weight (± 5%) for the past 3 months • Dieting or smoking current or in the past 3 months • Most prescribed medication or substance abuse within the past 6 months • Pregnant or lactating, not oral contraceptives

  8. Methods (Participants) • Inclusion Criteria • PE (medical history, ECG and blood tests) • Questionnaire on Eating and Weight Patterns • BED if they met the full criteria of DSM IV • Non-BED if they denied episodes of overeating BED (n=11) non-BED (n=11)

  9. Procedures • Body Composition (first day) • Waist and hip circumferences (WHR) • % Body Fat by underwater weighing • Psychological Scales • Zung Depression Rating Scales • CPT ( second day) • 12 hour fast and then a fixed meal • First blood draw @ 8-9 am • Immersed non-dominant hand in 2 min of 0° C ice water • Rated Pain, Stress, Hunger and Desire to Binge Eat • Blood draws at –10 , 0, 5,15, 30, 45 and 60 min • Blood pressure and heart rate

  10. Procedures (More) • DST (third day) • 1 mg oral dexamethasone @ 11 pm • Blood drawn @ ~8am for CORT

  11. Results

  12. Results

  13. Results

  14. Results • Insulin • No differences • DST • No difference between BED and non-BED • BED compared with morning CORT relative greater reduction • VAS Ratings • BED had greater AUC hunger, desire to binge eat, pain, stress

  15. Results

  16. Results • Sympathetic Activity • No Differences • Correlations • AUC for CORT was correlated w/ AUC pain • AUC for Stress was correlated w/ AUC “desire to binge eat” and Pain • AUC Pain was correlated Hunger and “desire to binge eat”

  17. Results

More Related