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Outline:

Outline:. Invasion Penetrating barriers Avoiding the Host Defenses Hiding within a host cell Avoiding killing by CSP Avoiding destruction by phagocytes Avoiding antibodies. Invasion : Breaching Anatomical Barriers. Find new niche with few competitors Gain access to rich nutrient supply

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Outline:

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  1. Outline: • Invasion • Penetrating barriers • Avoiding the Host Defenses • Hiding within a host cell • Avoiding killing by CSP • Avoiding destruction by phagocytes • Avoiding antibodies

  2. Invasion: Breaching Anatomical Barriers • Find new niche with few competitors • Gain access to rich nutrient supply • 1. Skin: tough barrier, rely on skin-damaging injuries (wounds, cuts) (Staphylococcus aureus) • 2. Crossing mucous membrane (e.g. intestinal epithelial cells) (Most pathogens)

  3. Ruffling method of invasion

  4. Avoiding the Host Defenses • 1. Hiding within host cells • Cell-to-cell Spreading Shigella and Listeriaspecies

  5. Avoiding the Host Defenses • 2. Avoiding complement killing • Gram- bacteria are susceptible to MAC because their outer membrane serves as a target. • Serum resistant bacteria • The same mechanism as the host cells use

  6. Avoiding the Host Defenses • Avoiding destruction by phagocytes

  7. Avoiding the Host Defenses Avoiding Antibodies 1. 2. 3.

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