1 / 6

Biochemical Test

Biochemical Test. Serum Calcium to confirm increase in calcium as action of the parathyrod hormone Normal: 8.5 mg/ dL Normal ionized: 4.4 – 5.2 mg/ dL Elevated calcium be tested with level of PTH for: hyperparathyroidism Malignancy. Izza. Biochemical Test. Parathyroid Hormone (PTH)

majed
Download Presentation

Biochemical Test

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Biochemical Test • Serum Calcium • to confirm increase in calcium as action of the parathyrod hormone • Normal: 8.5 mg/dL • Normal ionized: 4.4 – 5.2 mg/dL • Elevated calcium be tested with level of PTH for: • hyperparathyroidism • Malignancy Izza

  2. Biochemical Test • Parathyroid Hormone (PTH) • Normal: 10 - 50 mg/dL • can distinguish PHPT vs other causes of hypercalcemia • hypercalcemia + intact PTH = PHPT • Hypercalcemia + low PTH = malignancy • Elevated parathyroid hormone (PTH) levels in the setting of hypercalcemia establish the diagnosis of hyperparathyroidism Izza

  3. Biochemical Test • Serum phosphate • decreased serum phosphate level of less than 2.5 mg/dL (0.81 mmol/L) • Cl: PO4 ratio is elevated = mild hyperchloremic acidosis (>33) • Calcium - Creatinine Ratio : elevated (>0.02) • Normal: <0.01 Izza

  4. Biochemical Test • Urinalysis • For patients not previously documented normocalcemia or a family history of hypercalcemia • Elevated 24 hr urinary calcium: benign familial hypocalciurichypercalcemia (BFHH) • >100 mg/day • Normal or increase in uric acid • Unchange or decrease in Mg • Alkaline phosphatase • increase due to Increased bone turnover reflected as elevated levels of markers of bone formation • marker of bone resorption is also noted: increase urinary pyridinoline • present in 10% of patients with PHPT Izza

  5. Biochemical Test • Vitamin D3 • Occasionally normal of increased • Normocalcemic PHPT • Vit. D deficiency • Low serum albumin • Excessive hydration • High phosphate diet Izza

  6. Laboratory test result • Serum calcium = 20 mg/dLelevated • Ionized calcium = 8 mg/dLelevated • Serum PTH level = 70 mg/dLelevated • Hypercalcemia + elevated PTH level • rule out malignancy • hyperparathyroidism Izza

More Related