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More than an immune booster

More than an immune booster. Schedule. Basics Avemar and Immunovet Production Effects Results. Introduction. Albert Szent-Györgyi (Hungarian Nobel laureate) Biochemical research with fermented wheat germ Effective molecule complex against cancer cells

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More than an immune booster

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  1. More than an immune booster

  2. Schedule • Basics • Avemar and Immunovet • Production • Effects • Results

  3. Introduction • Albert Szent-Györgyi (Hungarian Nobel laureate) • Biochemical research with fermented wheat germ • Effective molecule complex against cancer cells • Development by Hungarian sciencists, inspired by His legacy • Avemar available from 1998

  4. Avemarand Immunovet – FWGE • Raw materials • Manufacturing technology • fermentation • extraction • standardization (2,6 dimethoxy-p-benzoquinone) • Similarities • same manufacturing line • one fermentative mass • Differences • different fractions of the fermented mass • different goal

  5. Immunovet • Raw materials • wheat germ • yeast • Special fermentation process • Extraction of active compounds • Drying, concentration and standardization • Tablet pressing and boxing

  6. Fermented Wheat Germ Extract • Goal is the prevention of healthy status • Healthy • Not equal to not sick

  7. FWGE – cell-level effects 1. • Pentose Phosphate Pathway (PPP) • Glucose  Ribose5Phosphate  mRNA  DNA replication • FWGE blocks Transketolase (Glucose  Ribose5Phosphate) • DNA replication stops, non-oxidative way slows • Selective effect for cancer cells (why?)

  8. FWGE – cell-level effects 2. • Apoptosis induction • Poly-(ADP-Ribose)-Polimerase (PARP) important in the repairing of DNA-chains • Extremely high activity in cancer cells • FWGE aktivates the proteolysis of PARP • A DNS-repairing impairs, thus DNA chains fragment

  9. FWGE – cell-level effects 3. • FWGE block the synthesis of MHC-I molecules in cancer cells • Major histocompatibility complex (ID card to present for Leukocytes) • No MHC1  not friendly • NK cells activate

  10. FWGE – cell-level effects 4. • ICAM-1 (intercellular adhesion molecule) • Stabilizes the cell-cell interaction, facilitates the leucocyte entdothelial transmigration • Downregulated on surface of tumor vessels – no help for leucocytic infiltration • FWGE upregulates ICAM-1 expression, making leucocytic infiltration easier

  11. FWGE – anti-inflammatory • COX 1 and 2 non selective inhibitor – immunmodulation, anti-inflammatory effect

  12. Reconvalescence time After bone surgeries

  13. Clinical status in contagious diseases (used PARALLEL the veterinary treatment)

  14. Clinical status in oncologic cases (used PARALLEL the veterinary treatment)

  15. Immunovet • Available since 2002 • Millions of animals, so far no adverse effect • Not toxic („like a slice of bread”) • LD50 > 2500mg/bwkg

  16. Immunovet

  17. Immunovet tablets • Easy to administer • Good taste, willing to eat

  18. Immunovet • Young animals – quick growth • Hair change • Stress • Chronic diseases • After surgeries • Elder animals – general boost

  19. Immunovet • With the recommendation of the Hungarian Veterinary Chamber • With the recommendation of the Hungarian Kennel Club

  20. Thank you for the attention!

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