PROLIFERAZIONE CELLULARE E RESISTENZA AI FARMACI

1. PROLIFERAZIONE CELLULARE E RESISTENZA AI FARMACI

2. CANCER • Cancer is characterized by abnormal, unrelated cell proliferation • Cancer invades healthy tissues and compete with normal cells for oxygen, nutrients, and space • Abnormal cells reproduce in the same way as normal cells, but they do not have the regulatory mechanisms to control growth • The abnormal cell growth proliferates in an uncontrolled and unrestricted way.

3. CANCER • Tumors are also classified according to their cell of origin and whether their growth is benign or malignant • BENIGN tumors remain at their site of origin • They may grow large, but their growth rate is slower than that of malignant tumors • They usually do not cause death unless their location impairs the function of a vital organ • MALIGNANT tumors grow rapidly are likely to undergo metastasis (See table 20-2)

4. Benign vs malignant

5. Epithelial cells = carcinomasConnective tissues or muscle = sarcomasHemopoietic cells = leukemiasPigments producing cells of the skin = melanoma

6. 6 key behaviors of cancer cells • They disregard the external and internal signals that regulate cell proliferation • They are resistant to apoptosis • The avoid limitations to proliferation, such as differentiation and senescence • They are genetically unstable • They are invasive (escape home tissue) • The metastasize (survive and proliferate in foreign tissues)

7. Clonal Evolution

8. Genetic Instability and Tumor Progression

9. Normal and deranged control of cell production from stem cells

10. Dominant and recessive cancer genes

11. Ways to make a proto-oncogene overactive

12. The genetic mechanisms underlying retinoblastoma

13. Rb Protein

14. Major signaling pathways relevant to cancer

31. p53

33. Telomerase is reactivated in Human cancers