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Longer Life, Better Life

Longer Life, Better Life. ——Current research progress on Alzheimer Disease. Presenter: 陈昊 Representing The third group. 21 st century--time for the aged. Number of the aged is so huge!. 0.7 billion is the old! Almost 1 in 10 on the world is over 60!. VS. October 31st, 2011

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Longer Life, Better Life

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  1. Longer Life, Better Life ——Current research progress on Alzheimer Disease Presenter:陈昊 Representing The third group

  2. 21st century--time for the aged Number of the aged is so huge! 0.7 billion is the old! Almost 1 in 10 on the world is over 60! VS October 31st, 2011 7 billion people on the world?

  3. Aging is everywhere! 4-5 times increasing in 50 years, just like a rocket! What about China? The pace is faster. Number of the aged (current and predicted) of some continents

  4. The Result of aging: Enjoy a longer life CIA World Fact book 2007 : Over 100 nations or regions enjoy the life expectancy over 70! ? Quality of life? Life expectancy worldwide on 2007 From Wikipedia

  5. Living quality---A better life as well? The tragedy of aging: Economic influence Aging is good or not? This is a question. Social problems Health and diseases

  6. The position of Alzheimer When we become old…… Stroke CHF diabetes Aged diseases Cancer Neurodegenerative disease hypertension Alzheimer

  7. 1 The characters of Alzheimer 2 Alzheimer----the killer of life quality 3 Research on Mechanism of Alzheimer 4 Current drug and therapy 5 Can Alzheimer be prevented? Contents Fight against Alzheimer!

  8. 1 Alzheimer--- four stages characters Severe Early Middle Final • slow, progressive loss of intellectual ability • difficulty learning • mild depression • cannot speak or walk, even breathe • has profound memory loss • an increase in memoryloss • Decrease losing of daily living ability • unabletorecognize objects and family members Buckley LL; Schub T; Pravikoff D; Quick lessons about Alzheimer Disease. Cinahl Information Systems, 2011 Sep 30

  9. Epidemiology: the high rate of AD in the aged The older one is, the more risky on getting AD! The percentage of AD (%)

  10. 2. Alzheimer destroys the quality of life Danger of the patients 15-20 years! cognition loss ??? Remember loss Ability loss

  11. Alzheimer destroys the quality of life Social problems Living without quality or die at once, this is a question! Have you remembered or not? ! Mercy killing! TEMPORARY INSANITY: THE STRANGE LIFE AND TIMES OF THE PERFECT DEFENSE. Boston University Law Review. October, 2011. 1660-1661

  12. The mechanism Of Alzheimer Cholinergic hypothesis Amyloid hypothesis 3.The mechanism of Alzheimer—so many hypothesis imbalance Rubbish in brain! Acetylcholine (ACh) production elimination ? 11C-PIB PET images characteristic Christiane Reitz. Epidemiology of Alzheimer disease. Nat. Rev. Neurol. 7, 137–152 (2011)

  13. New research: The interaction between these hypothesis Amyloid hypothesis to Cholinergic one: The more rubbish, the less Ach is! MagdolnaPa´ka´ski, Ja´nosKa´lma´n. Interactions between the amyloid and cholinergic mechanisms in Alzheimer’s disease. Neurochemistry International. 2008. 53. 103-111

  14. New research: The interaction between these hypothesis Cholinergic hypothesis to Amyloid one: Ach inhibits the rubbish’s producing! amyloid MagdolnaPa´ka´ski, Ja´nosKa´lma´n. Interactions between the amyloid and cholinergic mechanisms in Alzheimer’s disease. Neurochemistry International. 2008. 53. 103-111

  15. Current Drug for AD H3 antagonist ACEIs 5-HT receptor New ACEIs 4.Current Drug and therapy Donepezil Rivastigmine Galantamine …… Ciproxifan 2009 Thioperamide 2006 Anti-depressant only? Mianserin5-HT2A antagonist Effect in cognition loss 2004 Huperzine A Alvin V. Terry Jr, Patrick M. Callahan, Brandon Hall, Scott J. Webster. Alzheimer's disease and age-related memory decline (preclinical). Pharmacology, Biochemistry and Behavior 99 (2011) 190–210

  16. A large market in AD drug and therapy • Drugs for AD have a large market.

  17. The mechanism of ACEIs X decompose Ach Re-uptake The Cholinergic pass way AChE: Acetylcholinesterase

  18. 5. Can Alzheimer be prevented? Biotech therapy anti-amyloid Therapy? Virus-like Vaccine? Prevention Of AD Emotional Therapy? Chinese Traditional medicine? Self therapy Diet Therapy?

  19. Current research: Biotech vaccine Virus-like particle based vaccines for AD 2010 currently in human clinical trials High-affinity antibody anti- amyloid! Virus-like particle based antigen virus Bryce Chackerian. Virus-like particle based vaccines for Alzheimer disease. Human Vaccines.2010 Volume 6, Issue 11

  20. Mechanism clearer More drugs Better prevention Our love To the old? ---Live longer, live better! Conclusion live longer, live better. It’s not only for the old, but also for our future!

  21. Reference and acknowledgements 1 Buckley LL; Schub T; Pravikoff D; Quick lessons about Alzheimer Disease. Cinahl Information Systems, 2011 Sep 30 2 TEMPORARY INSANITY: THE STRANGE LIFE AND TIMES OF THE PERFECT DEFENSE. Boston University Law Review. October, 2011. 1660-1661 3 Christiane Reitz. Epidemiology of Alzheimer disease. Nat. Rev. Neurol. 7, 137–152 (2011) 4 MagdolnaPa´ka´ski, Ja´nosKa´lma´n. Interactions between the amyloid and cholinergic mechanisms in Alzheimer’s disease. Neurochemistry International. 2008. 53. 103-111 5 Alvin V. Terry Jr, Patrick M. Callahan, Brandon Hall, Scott J. Webster. Alzheimer's disease and age-related memory decline (preclinical). Pharmacology, Biochemistry and Behavior 99 (2011) 190–210 6 Bryce Chackerian. Virus-like particle based vaccines for Alzheimer disease. Human Vaccines.2010 Volume 6, Issue 11

  22. Thank You ! Honor product of F0917101TM Scientific 药院出品，必属佳作 We not only focus on study progress, but also the research areas around the world!

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