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No Moral, Legal, Ethical or Religious Issues

No Moral, Legal, Ethical or Religious Issues. What are the benefits?. Dental Benefits (Practice). Ability to offer a service that will potentially cure or save a patients life. Additional source of marketing for your practice (patient for life). Dental Benefits (Patient).

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No Moral, Legal, Ethical or Religious Issues

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  1. No Moral, Legal, Ethical or Religious Issues

  2. What are the benefits?

  3. Dental Benefits (Practice) • Ability to offer a service that will potentially cure or save a patients life. • Additional source of marketing for your practice (patient for life).

  4. Dental Benefits (Patient) • Tissue Regeneration : The ability to cure gum disease by regenerating healthy gum tissue. • Bone regeneration : The ability to grow bone for tooth regeneration and jaw recreation. • Nerve Regeneration : Potential to regrow healthy nerves for multiple applications in dentistry and beyond

  5. Manage Endo • Advancement in use of DPSCs have added advantage in the field of Endodontic where, we can develop human dental pulp in the laboratory. • These outcomes provide evidence suggesting that it might be feasible to restore viability in a necrotic young permanent tooth by engineering a new dental pulp.

  6. Clinical Implications of the Study • Future regenerative endodontic treatment may involve the cleaning and shaping of root canals followed by the implantation of vital dental pulp tissue constructs created in the laboratory. JADAApril 2008 Volume 139, Issue 4, Pages 457–465 ; Eric L. Gotlieb, DDS, Peter E. Murray, PhD, Kenneth N. Namerow, DDS, Sergio Kuttler, DDS, Franklin Garcia-Godey, DDS, MS

  7. Growing Teeth from Stem Cells

  8. Manage Periodontal Disease • Now day, dentist can very well manage periodontal diseases by using stem cell and scaffold technology[*]. • However, making whole artificial tooth and periodontal frame work by this technology is a challenge for scientists working in the field dental regenerative therapies. • It is now well established that most of the dental related problems can be treated by using DPSCs alone or in combination with scaffold technology[**]. • * Abou Neel EA, Chrzanowski W, Salih VM, Kim HW, Knowles JC. Tissue engineering in dentistry. J Dent 2014; 42: 915-928 [PMID: 24880036 DOI: 10.1016/j.jdent.2014.05.008] • ** Ji J, Sun W, Wang W, Munyombwe T, Yang XB. The effect of mechanical loading on osteogenesis of human dental pulp stromal cells in a novel in vitro model. Cell Tissue Res 2014; 358: 123-133 [PMID: 24916612 DOI: 10.1007/s00441-014-1907-8]

  9. Scaffolding for a Tooth

  10. Clinical Benefits • Ability to multiply indefinitely (UNLIKE umbilical cord cells) Can be used by multiple family members. • Current Stem Cell Applications • Cancers (Leukemia, Lymphoma), Metabolic Disorders, Gum Disease, Bone Marrow, Immunodeficiencies, Failure Syndromes, Cardiovascular diseases, Spinal Cord injury, Bond/Cartilage repair, multiple sclerosis. • Emerging Stem Cell Applications: • Stroke, Type 1 Diabetes, Brain Injury, Corneal Damage, Hearing Loss, Cerebral Palsy, Autism, Muscular Dystrophy, Alzheimer's, Parkinson’s, Tooth Loss, Jawbone Regeneration, Facial Reconstruction, Heart Defects, Heart Attack, Kidney Disease, Deafness, Crohn’s disease.

  11. Applications • Heart Disease: Repair of cardiac muscle • Eyes: Used to regain sight after injury • Skin: Skin grafts after burn or reconstructive surgery • Nerve Repair: Spinal cord, Peripheral nerve and brain damage • Regenerate Brain Cells: To treat Parkinson’s, Alzheimer’s and other motor neuron diseases • Replacement bone, cartilage, and tissue

  12. Growing Cartilage The "mouse-ear" project began in 1989, when Charles Vacanti (brother of Joseph) managed to grow a small piece of human cartilage on a biodegradable scaffold.

  13. Before and after corneal surgery Stem cells from dental pulp can be turned into corneal cells, study says • Stem cells from the dental pulp can be coaxed to turn into cells of the eye’s cornea and could one day be used to repair corneal scarring due to infection or injury, according to researchers at the University of Pittsburgh School of Medicine. • Shortages and rejection currently • Cells are your own with little or no rejection • “They have great potential for use in regenerative therapies.” Dr. Syed-Picard noted. • ADA News - March 02, 2015

  14. Tooth Stem Cells • Human Stem Cells Shape a New approach to Autism Research • Study finds stem cells can be manipulated to promote bone growth • A new study has identified an enzyme in mesenchymal stem cells (MSC’s) that is responsible for creating either bone or fat – a finding that scientists argue may lay the groundwork for new osteoporosis and obesity treatments. Study: Stem cells can regenerate jawbone to hold dental implants.

  15. Tooth Stem Cells • Cement, Stem cells make for a good Bone graft – • Stem Cells and Calcium Phosphate Cement Scaffolds for Bone Regeneration, Wang P, zhao L, et al: J Dent Res 2014; 93 (May 5): 618-625. Natural Dental Implants - The Tooth – A Treasure Chest of Stem Cells, Volponi AA, Sharpe PT: Br Dent J 2013; 215 (October 12): 353-358.

  16. Clinical Trials by Disease Type

  17. Medical Future • Dental Stem Cells and Regenerative Medicine • Dental Stem Cells have the ability to multiply endlessly, which gives a patient the ability to have them for their entire life and used multiple times. • Dental Stem Cells are similar to Bone-Marrow Stem Cells, except much easier, less painful to access. • Dental Stem Cells reach is much more than just a patients oral health. It is the patients entire overall health that is being targeted, as you will learn more about the benefits in the following slides.

  18. Cost to save tissues • Bone Marrow - $80,000 – 400,000 • Umbilical cord - cost $2,000 + (one time use) • Teeth - cost $500 (Endless use)

  19. Companies Providing Stem Cell Services • Toothbank $590.00 • www.toothbank.com • Bioeden $999.00 • www.bioden.com • Store-A-Tooth $1,700.00 • www.storeatooth.com • Stem Save $750.00 • www.stemsave.com

  20. Tooth Bank - Competitive Edge • Collaboration with the Mayo Clinic to discover transformational medical advancements with dental stem cells • Affordable Annual Storage Fees • Process 7 Days a week • Free cell multiplication if needed • Free Shipping • Less than your Children’s other fees (Athletics, Education, etc.) • Technology • Experience • Regulations (FDA Registered and Approved)

  21. Final Thoughts from Dentists • Ability to offer a possible life-saving service to our patients at an affordable cost. • Don’t ask yourself, “Why would I offer this to my patients?” Ask yourself, “Why wouldn’t I offer this to my patients?”

  22. Don’t Throw Away Baby’s Teeth: They Can Save Your Child’s Life • By storing your own teeth or your child’s teeth you are helping insure their future. • Wisdom teeth are one of the most viable sources of stem cells. • By banking, it adds peace of mind.

  23. AAPD Statement • The AAPD stance on Dental Stem Cells: “The American Academy of Pediatric Dentistry recognizes the emerging field of regenerative medicine and encourages dentists to follow future evidence-based literature in order to educate parents about the collection, storage, viability, and use of dental stem cells with respect to autologous regenerative therapies.” • Def. autologous -(of cells or tissues) obtained from the same individual

  24. Scientific Articles • Mesenchymal stem cells in joint disease and repair.Mesenchymal stem cells in joint disease and repair.Nat Rev Rheumatol. 2013 Oct ;9(10):584-94. doi: 10.1038/nrrheum.2013.109. Epub 2013 Jul 23 . • Mesenchymal stem cell therapy for osteoarthritis: current perspectivesMesenchymal stem cell therapy for osteoarthritis: current perspectivesStem Cells and Cloning : Advances and Applications. 2015; 8()117 • Dental pulp tissue engineering in full-length human root canals.Dental pulp tissue engineering in full-length human root canals.J Dent Res. 2013 Nov ;92(11):970-5. doi: 10.1177/0022034513505772. Epub 2013 Sep 20 . • Stem cells: A potential regenerative future in dentistry

  25. Scientific Articles • Redefining the potential applications of dental stem cells: An asset for future.[Indian J Hum Genet. 2012]Redefining the potential applications of dental stem cells: An asset for future.Rai S, Kaur M, Kaur S, Arora SP. Indian J Hum Genet. 2012 Sep; 18(3):276-84. • Review Mesenchymal stem cells in the dental tissues: perspectives for tissue regeneration.[Braz Dent J. 2011]Review Mesenchymal stem cells in the dental tissues: perspectives for tissue regeneration.Estrela C, Alencar AH, Kitten GT, Vencio EF, Gava E. Braz Dent J. 2011; 22(2):91-8. • Review Stem cells: therapeutic potential in dentistry.[J Contemp Dent Pract. 2009]Review Stem cells: therapeutic potential in dentistry.Nedel F, André Dde A, de Oliveira IO, Cordeiro MM, Casagrande L, Tarquinio SB, Nor JE, Demarco FF. J Contemp Dent Pract. 2009 Jul 1; 10(4):90-6. Epub 2009 Jul 1. • Review Mesenchymal dental stem cells in regenerative dentistry.[Med Oral Patol Oral Cir Bucal....]Review Mesenchymal dental stem cells in regenerative dentistry.Rodríguez-Lozano FJ, Insausti CL, Iniesta F, Blanquer M, Ramírez MD, Meseguer L, Meseguer-Henarejos AB, Marín N, Martínez S, Moraleda JM. Med Oral Patol Oral Cir Bucal. 2012 Nov 1; 17(6):e1062-7. Epub 2012 Nov 1. • Stem cells in dentistry and medicine: the dentist's role. • Pub Med – Search: Dental Stem Cells – 4344 articles

  26. VivaLearning.com

  27. Thank you!

  28. CBS News in West Palm Beach, May 2011 reports on Dental Stem Cells • https://youtu.be/bu3ZJI7Af40

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