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Neuregulin and Schizophrenia

Neuregulin and Schizophrenia. Schizophrenia. Debilitating mental illness affecting 1 % of the general population across the world. Onset in adolescent age. Symptoms Positive symptoms Hallucinations, delusions Negative symptoms Avolition, Apathy Disorganization symptoms

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Neuregulin and Schizophrenia

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  1. Neuregulin andSchizophrenia

  2. Schizophrenia • Debilitating mental illness affecting 1 % of the general population across the world. • Onset in adolescent age. Symptoms • Positive symptoms • Hallucinations, delusions • Negative symptoms • Avolition, Apathy • Disorganization symptoms • Inappropriate social behavior • Cognitive deficits • Perceptual deficits - Visual, Auditory. • Deficits in memory. • Emotional changes.

  3. Schizophrenia is associated with many alterations in brain structure and function. Many regional reduction in gray matter. Reduction in brain activation during cognitive tasks Van der stelt et al., , 2005 Thompson et al., , 2001 Achim et al., , 2005

  4. Genetics of Schizophrenia Kirov et al., , 2003

  5. Neuregulin 1 – Linkage in 8p Stefansson et al., 2002

  6. Harrison et al., 2006

  7. Functions of Neuregulin

  8. Flames et al., 2004

  9. Chih et al., 2004

  10. Michailo et al., 2004

  11. Conclusions • Evidences so far, show NRG plays a vital role in neurodevelopmental processes. • Association with Schizophrenia and late onset Alzhimer’s suggest a link between this gene and various diseases of nervous system. • The role of NRG is still being studied. Further studies are required to identify its mechanisms of action.

  12. Catpa demo….

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