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Radiation-resistance?  There's a Gene for That.

Radiation-resistance?  There's a Gene for That. New York City Wetware  iGEM Team. Extraordinary Biology Numbers. Extremophile Numbers Extraordinary Synthetic Biology Numbers. 130 MPa. 130 Celsius. 1.08-mega-base pair. 4 Days. Deinococcus radiodurans (D. rad). 12,000 Gray!!!!!.

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Radiation-resistance?  There's a Gene for That.

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  1. Radiation-resistance? There's a Gene for That. New York City Wetware  iGEM Team

  2. Extraordinary Biology Numbers Extremophile Numbers Extraordinary Synthetic Biology Numbers 130 MPa 130 Celsius 1.08-mega-base pair 4 Days

  3. Deinococcusradiodurans (D. rad) 12,000 Gray!!!!! One to two hours of acute six to ten Gray radiation exposure.

  4. Life of the Cell

  5. Base Damage Single Strand Break Double Strand Break A Bad Day Active Site Damage

  6. The Extraordinary Weapon (Kryptonite) • H2O  H· + OH· • OH· + OH·  H2O2 • Fe2+ + H2O2 → Fe3+ + OH· + OH− • Generation of Hydroxyl Radical via the Fenton Reaction

  7. What Makes D. rad So Special? Three Basic Approaches • Cellular Manganese-Iron Ratios • Neutralization of Superoxide Radicals • Superior DNA Repair Mn Fe O-

  8. What Makes D. rad So Special? Three Basic Approaches • Cellular Manganese-Iron Ratios Mn Fe

  9. What Makes D. rad So Special? Three Basic Approaches • Neutralization of Superoxide Radicals O-

  10. What Makes D. rad So Special? Three Basic Approaches • Superior DNA Repair recA Repair Protein

  11. Making E. coli Radioresistant O- DNA Repair Mn/Fe Our MegaBrick

  12. Our Biobricks • ruvA • tpx • ruvA • ruvB • radA

  13. Future Applications Bioremediation Waste Hungry Bacteria MegaBrick Clean Earth

  14. Future Applications Medical Applications Stem Cells MegaBrick Sick Person Healthy Person

  15. in vitro meat and moral traditions

  16. Kosher Vegetarian Vegan

  17. Legal Precedent: Gelatin

  18. Legal Precedent: Rennet

  19. Moral Considerations • Ought a vegan or vegetarian to eat meat? • Ought a kosher-observer to eat pork? • Does cultivating meat without encountering an animal desensitize us as eaters? Does it undermine the relationship between ourselves and animals?

  20. Our Sponsors

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