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HADD Patch

BACKGROUND. Transdermal Drug Delivery: The passive diffusion of drug molecules through the skin layers into the circulatory system due to a concentration gradient Prevalence: Birth Control, Angina, Pain, Motion Sickness, and Smoking Cessation Aid. BACKGROUND. Advantages: Avoid metabolism by ga

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HADD Patch

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    1. HADD Patch Senior Design Conference Louisiana Tech University Dept. of Biomedical Engineering May 9, 2003

    2. BACKGROUND Transdermal Drug Delivery: The passive diffusion of drug molecules through the skin layers into the circulatory system due to a concentration gradient Prevalence: Birth Control, Angina, Pain, Motion Sickness, and Smoking Cessation Aid

    3. BACKGROUND Advantages: Avoid metabolism by gastrointestinal tract Improves patient compliance Multi-day therapy in a single application Limitations: Stratum corneum limits rate of diffusion Molecular weight Lipophilicity

    4. PROJECT GOAL Problem: Drug delivery system must be augmented in such a way as to increase delivery rate of drug HADD Patch Project Goals: Determine optimal temperature for significant increase in drug delivery rate Create portable and disposable heat source

    5. DESIGN CRITERIA Diffusion must increase by approx. 100% Penetrant must not irritate or damage skin tissue Zero-order kinetics must be retained Applicable to current systems

    6. METHODS: THEORETICAL CONCEPTS

    7. METHODS: THEORETICAL CONCEPTS

    8. METHODS: THEORETICAL CONCEPTS

    9. METHODS: THEORETICAL CONCEPTS

    10. METHODS: THEORETICAL CONCEPTS

    11. METHODS: THEORETICAL CONCEPTS

    12. TESTS, RESULTS AND ERRORS Dissolution Franz cell diffusion test Heat optimization test Skin conductance

    13. METHODS: DRUG DISSOLUTUION TEST Mention UV spectrometer and how we calibrated the curve THINK ABOUT STANDARD CURVEMention UV spectrometer and how we calibrated the curve THINK ABOUT STANDARD CURVE

    14. RESULTS: DISSOLUTION TEST

    15. RESULTS: DISSOLUTION TEST

    16. METHODS: FRANZ CELL DIFFUSION TESTER

    17. RESULTS: FRANZ CELL TEST

    18. RESULTS: FRANZ CELL TEST

    19. RESULTS: FRANZ CELL TEST NULL HYPOTHESIS: The average concentration of the control (T=32?) is higher than that of the average test concentration (T=39 ?) P-value = 8.428 * 10^-3 Reject null hypothesis if |t|> T t= -2.958 and T = 2.101 The null hypothesis was rejected therefore the expected value of concentration at 39 ?C is higher than that of concentration at 32 ? C

    20. ERROR IN DIFFUSION & DISSOLUTION TESTS Oil in couvette Significant loss of product with each sample Heat was not ideally distributed

    21. METHODS: HEAT OPTIMIZATION

    22. RESULTS: HEAT OPTIMIZATION

    23. RESULTS: HEAT OPTIMIZATION NULL HYPOTHESIS: 5 small pin-holes effect a greater temperature than 1 large pin-hole P-value = 0.207 Reject null hypothesis if |t|> T t= 1.315 and T = 2.12 The results are inconclusive because the p-value is greater than 0.05

    24. METHODS: SKIN CONDUCTANCE

    25. RESULTS: SKIN CONDUCTANCE

    26. RESULTS: SKIN CONDUCTANCE

    27. ERROR IN SKIN CONDUCTANCE TEST Instrument drift Recalibration Emotional influence Artifacts in baseline signal Uneven distribution of heat

    28. CONSTRUCTION

    29. CONSTRUCTION WARNING: For transdermal use only. Other uses may result in damage to the eyes, throat, or soft tissues. WARNING: Do not cover patch with clothing as this will slow drug delivery.

    30. DISCUSSION: Heat Profile

    31. DISCUSSION: Ideal vs. Prototype Imperfect Insulation Temperature @ Aluminum/gel interface was predicted to be 39? C Lack of adhesive

    32. CONCLUSIONS Criteria Satisfaction The heat was shown to increase the rate of dissolution. The gel maintained zero-order kinetics. It was shown that skin conductance increased with an increase in temperature. The temperature of the heat source did not exceed 42? C and therefore does not irritate or damage tissue.

    33. FUTURE WORK Finite difference method for mass and heat transport as functions of time Adhesive Testing Animal Testing Expanding Drug Selection Miniaturization

    34. ACKNOWLEGEMENTS Dr. Mel de Villiers Marcia Pool Victoria Mickail Lester Smith Mary Caldorera Dr. Steven Amos Jones   Dr. Schubert Dr. Mills   Anna Hannibal

    35. QUESTIONS

    36. COST ANALYSIS

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