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Integrative Biophysics and Pulsed Electromagnetic Field Therapy

Integrative Biophysics and Pulsed Electromagnetic Field Therapy. Keith R. Holden, M.D. Resonance Center Jacksonville Beach, FL www.ResonanceCenterJax.com. Outline. Integrative Biophysics. Pulsed Electromagnetic Field (PEMF) Therapy as an instrument of integrative biophysics.

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Integrative Biophysics and Pulsed Electromagnetic Field Therapy

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  1. Integrative Biophysics and Pulsed Electromagnetic Field Therapy Keith R. Holden, M.D. Resonance Center Jacksonville Beach, FL www.ResonanceCenterJax.com

  2. Outline • Integrative Biophysics. • Pulsed Electromagnetic Field (PEMF) Therapy as an instrument of integrative biophysics. • Biomolecular effects. • Epigenetic effects. • Cellular physiologic effects.

  3. Outline cont. • Optimal tissue frequencies. • Proof of efficacy via peer reviewed studies, including RDBPC clinical trials. • Ondamed® as a powerful instrument of integrative biophysics.

  4. Integrative Biophysics • Holistic integration of quantum energetic, molecular, biochemical, and physiologic processes.

  5. Integrative Biophysics • Reflects the web-like interconnectedness of all biologic systems within the body and that of the body with its environment.

  6. Integrative Biophysics • Honors energetic and biochemical individuality.

  7. Integrative Biophysics • PEMF = instrument for integrative biophysics.

  8. PEMF Biomolecular Effects • Larmor Precession Model • External pulsed electromagnetic field matches the (Larmor) spin frequency of hydrogen atom causing energized electrons to emit a photon, which act as a vital energy carrier for tissue repair. • Ion/ligand binding at cell membrane. • Alters cascade of biological processes for tissue growth and repair.

  9. PEMF Biomolecular Effects • Amplification of the tissue repair field (current of injury).

  10. PEMF Epigenetic Effects • Upregulation of genes involved in normal cell growth. (Goodwin, 2003)

  11. PEMF CellularEffects • Increases osteoblast intracellular calcium & alters response to epidermal growth factor. (Shigaku,1990) • Stimulates production of type-I collagen, osteocalcin, & osteopontin. (Cornaglia, et al., 2006) • Antiinflammatory effect via restoration of plasma membrane calcium ATPase activity. (Selvam, et al., 2007)

  12. Frequencies for Tissues • Nerve‐2 Hz • Bone‐75 Hz • Ligament‐10 Hz • Capillaries and skin‐15 Hz (Sisken, et al., 1995) (Shupak, 2003)

  13. Frequencies for Conditions • Fracture non-union – 65-75Hz • Congenital pseudoarthrosis – 15Hz • Osteoporosis – 72Hz • Hip arthroplasty – 50Hz • Arthritis – 50Hz • Tinnitus – 0.5-17Hz • Rotator Cuff Tendonitis – 71-75Hz • Venous skin ulcers – 75Hz • Multiple sclerosis – 4-13Hz (Shupak, 2003)

  14. Clinical Trials Randomized, Double Blind, Placebo Controlled

  15. Chronic Lower Back Pain • Randomized double blind placebo controlled (RDBPC) clinical trial. • PEMF 3X a week for 3 weeks for chronic lower back pain. • Significant reduction in pain and disability over placebo. (Lee, 2006)

  16. Musculoskeletal Chronic Pain • RDBPC clinical trial. • Chronic generalized pain from fibromyalgia or chronic localized musculoskeletal pain. • PEMF twice daily 40 min. for 7 days. • PEMF effect over sham for fibromyalgia approached statistical significance. (Thomas, et al., 2007)

  17. Cervical Osteoarthritis • RDBPC clinical trial. • PEMF 30 min. 2X a day for 3 weeks. • Neck pain, PVMS, and disability scale scores decreased, and AROM increased significantly in the PEMF group. • No change in the sham group. (Sutbeyaz, et al., 2006)

  18. OA of knee and cervical spine • RDBPC clinical trial. • 86 patients with OA of knee. • 81 patients with OA of cervical spine. • Statistically significant improvement in treated patients for pain and ADLs at end of treatment and at one month follow up. (Trock, et al.,1994)

  19. Lateral epicondylitis • RDBPC clinical trial. • Group I (PEMF), Group II (sham PEMF), Group III (corticosteroid + anesthestic inj.) • Group III had lower pain than Group I and Group II at third week. • Group I (PEMF) patients had lower pain than Groups II and III at third month. (Uzunca, et al., 2007)

  20. ACL reconstruction • RDBPC clinical trial. • Preclinical studies show that PEMF limits catabolic effects of pro-inflammatory cytokines on articular cartilage. • PEMF 75 Hz 4 hours per day for 60 days. • Functional recovery occurs earlier with PEMF group. (Benazzo, et al., 2008)

  21. Fibromyalgia • RDBPC clinical trial. • PEMF 30 min. twice a day for 3 weeks. • At 12 weeks follow up, PEMF group showed significant improvements in pain compared to sham PEMF. (Sutbeyaz, et al., 2009)

  22. Arthroscopic knee surgery • RDBPC clinical trial. • PEMF for 90 days 6 hours per day. • PEMF group statistically significant improvement at 90 days. • NSAID use – PEMF (26%) & sham (75%). • 3 year follow up, number of patients who completely recovered was higher in PEMF. (Zorzi, et al., 2007)

  23. Multiple Sclerosis • RDBPC clinical trial. • PEMF 4 weeks. • Assessed MSQLI- fatigue, bladder control, spasticity, & QOL composite. • Statistically significant improvement in fatigue & QOL; none bladder control; mixed spasticity. (Lappin, et al., 2003)

  24. OA knee • RDBPC clinical trial. • PEMF 84 sessions for 30 min. • WOMAC index dec. 84.1 to 49.7 in PEMF and 73.7 to 66.9 in sham. • Secondary parameters improved over sham – gait speed, stride length, & acceleration time. (Nicolakis, et al., 2002)

  25. Interbody lumbar fusions • RDBPC clinical trial. • Active group – 92% success rate. • Sham group – 65% success rate. (Mooney, 1990)

  26. Rotator cuff tendinitis • RDBPC clinical trial. • Refractory rotator cuff tendinitis. • PEMF showed significant improvement over sham during the first four weeks. • No significant difference between groups when both received PEMF. • End of study – 65% were asymptomatic. (Binder, 1984)

  27. Conditions amenable to PEMF

  28. PEMF Impact on Cell Physiology Bassett, CA, Beneficial Effects of Electromagnetic Fields. J of Cell Biochemistry. 1993; 51:387-393.

  29. Fracture nonuinon, failed joint fusion, congenital pseudoarthrosis • T mineralization • T angiogenesis • T collagen + GAG production • Endochondral ossification • (T osteoclasis for pseudoarthrosis)

  30. Spinal fusion, osteonecrosis, and osteoporosis • T angiogenesis • T osteoblastic activity

  31. Chronic tendinitis andchronic skin ulcers • T angiogenesis • T collagen + GAG production

  32. Experimental Data: New Clinical Indications for PEMF? Bassett, CA, Beneficial Effects of Electromagnetic Fields. J of Cell Biochemistry. 1993; 51:387-393.

  33. Acute Myocardial Ischemia and Acute Cerebral Ischemia • Animal data showing decrease in infarct size. • Acute affects on blood flow and angiogenesis. • Questionable effect on superoxide dismutase and nitrous oxide.

  34. Cancer • Animal data demonstrate decreased growth and invasiveness of Meth A sarcoma in Balb C mice, encapsulation and nuclear changes.

  35. Periodontal disease, edentulous jaw, and extraction sockets • Animal data show decrease in bone resorption in jaws. • Increased osteogenesis in tooth extraction sockets. • Improved bacterial flora spectrum.

  36. Diabetes, adult onset • Clinical benefits on blood glucose reported. • ? Secondary to Ca++ effects on insulin secretion.

  37. Diabetic and alcoholic neuropathy • Effects on axoplasmic transport. • Neuronal protein synthesis. • Ca++/neurotransmitter effects at synapse. • Angiogenesis.

  38. Ligament/tendon healing • Animal data showing improved healing. • Increased collagen and GAG synthesis. • Increased angiogenesis.

  39. Peripheral nerve transection/crush • Animal data showing increased protein synthesis. • Increased axon migration and function.

  40. Spinal cord injury • No direct evidence. • Data on neuropathy and nerve transection may prove beneficial. • Particularly in crush injuries when sensory and motor potential evoked potentials are still present.

  41. ONDAMED • An integrative biophysics instrument that changes the energetic terrain. • Positive affects on biologic systems with low level specific pulsed electromagnetic frequencies. • Specific frequencies via pulse testing provide intelligent information.

  42. Recommended resources • Bassett, CA. Beneficial Effects of Electromagnetic Fields. J of Cell Biochemistry. 1993; 51:387-393. • Holden, K. Pulsed Electromagnetic Field Therapy With the Ondamed – A Tool for Integrative Biophysics. http://www.ondamed.net/web/publications/articles.html. 2009. • Shupak, N. Therapeutic Uses of Pulsed Magentic-Field Exposure: A Review. The Radio Science Bulletin. 2003 Dec; (307): 9-32.

  43. Contact Information Keith R. Holden, M.D. Resonance Center 496 Osceola Avenue Jacksonville Beach, FL 32250 (904) 694-0378 krholden@gmail.com www.ResonanceCenterJax.com

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