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Implementing Systemic Interventions to Close the Discovery-Delivery Gap

Implementing Systemic Interventions to Close the Discovery-Delivery Gap. 1 R01 CA124402-01A1 Bryan J. Weiner, Ph.D. (PI). Specific Aims. To inform the NIH Roadmap by examining the: Implementation Impact Sustainability Business case

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Implementing Systemic Interventions to Close the Discovery-Delivery Gap

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  1. Implementing Systemic Interventions to Close the Discovery-Delivery Gap 1 R01 CA124402-01A1 Bryan J. Weiner, Ph.D. (PI)

  2. Specific Aims To inform the NIH Roadmap by examining the: • Implementation • Impact • Sustainability • Business case of the Community Clinical Oncology Program (CCOP), a federally-funded, national provider-based research network (or PBRN)

  3. Goals • Inform the NIH about what it takes to implement and sustain PBRNs • Inform the NIH about what it can expect from PBRNs as a model for disseminating and implementing evidence-based clinical services in community-based practice settings • Inform NCI/DCP’s ongoing efforts to strengthen the CCOP network

  4. Prior Work • NCI/DCP contract to examine the integration of cancer prevention and control (CP/C) research into cooperative groups and CCOPs • NCI/DCP contract to examine CCOPs showing strong accrual to CP/C trials • Secondary data analysis of organizational, environmental, and network factors associated with CCOP survival and accrual performance

  5. A Unique Opportunity • The CCOP permits an examination of the impact of PBRNs as a model for disseminating evidence-based clinical services across a wide range of treatment modalities (e.g., surgery, radiation, and medical therapies). • With a 23-year history and with new CCOP organizations joining the program, the CCOP not only enables the investigation of start-up and early implementation, but also allows for the examination of mature implementation and sustainability.

  6. A Unique Opportunity • Extensive secondary data exist that describe the organization, operations, environment, performance, and clinical impact of CCOP organizations. • As a national network of 50 sites implementing a common set of clinical research protocols, the CCOP offers a large enough number of comparable sites to permit statistical analysis of quantitative data. • CCOP continues to serve as a model for the NIH

  7. Design Overview • Implementation • Study 1: Case studies of 3 three newly funded CCOPs • Study 2: Mailed survey of CCOP physicians and staff • Impact: • Study 3: Analysis of SEER-Medicare data • Sustainability • Study 4: Longitudinal analysis of secondary data • Business Case • Study 5: Case studies of 5 CCOPs

  8. What This Means for You • High-visibility project within NCI and (we expect) within NIH Roadmap community – enhance reputation of program • Direct involvement of CCOPs: • Study 1: Three newly funded CCOPs already on board – site visits to all 3 in each year, beginning Winter 2008 • Study 2: mailed survey effort to begin in Year 4 (2010) • Study 5: Will recruit 5 CCOPs – site visits to 1 per year

  9. Contact Information Bryan J. Weiner, Ph.D. Associate Professor UNC-Chapel Hill Phone: 919-966-7375 Email: bryan_weiner@unc.edu We look forward to working with you!

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