1 / 9

Chromosome Abnormalities

Chromosome Abnormalities. Changes in chromosomal structure. Chromosomal changes can occur spontaneously or from radiation or exposure to certain chemicals There are four means of chromosomal changes:. Deletion.

manon
Download Presentation

Chromosome Abnormalities

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Chromosome Abnormalities

  2. Changes in chromosomal structure • Chromosomal changes can occur spontaneously or from radiation or exposure to certain chemicals • There are four means of chromosomal changes:

  3. Deletion • In deletion, part of the chromosome is actually lost. Viruses, radiation and chemicals can cause a piece of a chromosome to become dislocated. • This piece may carry a specific gene which may have a large effect on the host.

  4. Cri-du-chat • Missing piece of chromosome 5 • Causes an abnormally developed larynx • Affected infants cries sound like the mewing of a cat

  5. Duplication • In duplication, a gene sequence is repeated one or more times within a chromosome • At some point, too many repeats can affect the function of the gene

  6. Fragile X Syndrome • A specific sequence on chromosome X, normally repeated 29 times, is repeated 700 times! • Most common cause of autism

  7. Inversion • In inversion, a gene segment momentarily becomes free from its chromosome and then reinserts in the opposite order. • This can completely alter the gene’s activities

  8. Translocation • In translocation, part of a chromosome changes place with another part of either the same or a non-homologous chromosome. • Translocation can result in some cancers, Down Syndrome, and leukemia

  9. Translocation and Disease • Linked to: • Cancer • Infertility: • Down syndrome

More Related