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Urso ML, Thompson PD, Clarkson P. et. al. ATVB 2005;25:2560 Umass

“We hypothesize that instability of the sarcolemmal membrane may be an effect of statin treatment, and when the integrity of the membrane is challenged in response to a bout of eccentric exercise , proteolytic cascades are activated in muscle.

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Urso ML, Thompson PD, Clarkson P. et. al. ATVB 2005;25:2560 Umass

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  1. “We hypothesize that instability of the sarcolemmal membrane may be an effect of statin treatment, and when the integrity of the membrane is challenged in response to a bout of eccentric exercise, proteolytic cascades are activated in muscle. This would explain the increase in the number of genes in protein catabolism (UPP) as well as lend support to the increase in the UPP genes.” Urso ML, Thompson PD, Clarkson P. et. al. ATVB 2005;25:2560 Umass

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