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ALL

ALL. Age <366 days. Interfant. t(9;22)/BCR-ABL+. EsPhALL. ALL11. Down syndrome. ALL11 Down. *no anthracyclines in induction *reduced MTX dose in prot M. No CR at day 33 or t(4;11)/MLL-AF4+. MRD. MRD. MRD MR or unknown or HR. MRD SR. MRD MR or unk. MRD HR. MRD SR. PPR

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ALL

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  1. ALL Age <366 days Interfant t(9;22)/BCR-ABL+ EsPhALL ALL11 Down syndrome ALL11 Down *no anthracyclines in induction *reduced MTX dose in prot M No CR at day 33 or t(4;11)/MLL-AF4+ MRD MRD MRD MR or unknown or HR MRD SR MRD MR or unk MRD HR MRD SR • PPR • CNS or testis involvement • PPR • CNS or testis involvement ALL11 SR ALL11 MR ALL11 HR ALL11 SR Down ALL11 MR Down 3 yr therapy incl anthracyclines 3 yr therapy incl anthracyclines in intensification IKZF del SCT ind IKZF del SCT 2 yr therapy no anthracyclines in intensification No SCT ind TEL/AML+ 2 yr chemoth 2 yr therapy no anthracyclines 2 yr therapy incl anthracyclines

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