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LS174T

Fig. S1. B. A. GLC82. H1299. Calu3. A549. H460. EGFR. p-EGFR. MEK 1/2. p-MEK 1/2. AKT. pAKT. RAS-Act. RAS-T. actina. LS174T. SW620. HCT116. HCT15. SW480. GEO. EGFR. p-EGFR. MEK 1/2. p-MEK 1/2. AKT. pAKT. RAS-Act. RAS-T. actina.

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LS174T

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  1. Fig. S1 B A GLC82 H1299 Calu3 A549 H460 EGFR p-EGFR MEK 1/2 p-MEK 1/2 AKT pAKT RAS-Act RAS-T actina LS174T SW620 HCT116 HCT15 SW480 GEO EGFR p-EGFR MEK 1/2 p-MEK 1/2 AKT pAKT RAS-Act RAS-T actina

  2. Table S.1A Mutation Status of Cell Lines Used in This Study KRAS

  3. KRAS

  4. Table S.1B Mutation Status of Cell Lines Used in This Study NRAS

  5. Table S.1C Mutation Status of Cell Lines Used in This Study BRAF

  6. Table S.1D Mutation Status of Cell Lines Used in This Study PIK3CA

  7. PIK3CA

  8. Table S.1E Mutation Status of Cell Lines Used in This Study P53 PTEN MEK 1/2

  9. Table S.1F Mutation Status of Cell Lines Used in This Study

  10. 8 5 0 6 0 1 0 0 0 Fig. S2 NRAS mutation KRAS mutation PIK3Ca mutation KRAS (G12and G13) mutation

  11. GEO GEO SW480 SW480 SW620 SW620 H1299 H1299 HCT116 HCT116 CALU3 CALU3 GLC82 GLC82 HCT15 HCT15 LS174T LS174T A549 A549 H460 H460 Fig. S7 Fig. S3

  12. P P P P RTK Fig. S4 GPCR ADCY7 β γ αs Grb2 SOS Shc ATP cAMP Ras PKA R AKAP13 Raf-1 PKA C MEK1/2 RA signaling NCOA3 TAF3 MAPK NR1H2 RXRA Cell survival Cell proliferatiom Cell proliferation Cell differentiation

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