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Pe 4/15

Supplementary S1. Pe 5/15. Pe 4/15. A. 3D. 2D. 3D. 2D. B. YAP. Pe 4/15. Pe 5/15. TAZ. SCD1. ALDH Bright cells (%). GAPDH. mRNA expression. Pe 4/15. Pe 5/15. C. D. Pe 5/15. Pe 4/15. % viability. Pe 5/15. Pe 4/15. Supplementary S2. A. B. Relative mRNA level.

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Pe 4/15

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  1. Supplementary S1 Pe 5/15 Pe 4/15 A 3D 2D 3D 2D B YAP Pe 4/15 Pe 5/15 TAZ SCD1 ALDH Bright cells (%) GAPDH mRNA expression Pe 4/15 Pe 5/15 C D Pe 5/15 Pe 4/15 % viability Pe 5/15 Pe 4/15

  2. Supplementary S2 A B Relative mRNA level ** ** Nuclear YAP/TAZ MF-438

  3. Supplementary S3 A B C G H I D E F L M N

  4. Supplementary S4 CTR 30 µm 30 µm 30 µm MF-438 30 µm 30 µm 18 µm

  5. Supplementary S5 A B C siSCD1 Pe 4/15 siCTR YAP CTR C59 RLU 8X-GTIIC ** * TAZ * Relative mRNAlevel Axin2 RLU TOP/FOP-FLASH SCD1 GAPDH YAP TAZ D E GAPDH CTR ** C59 N°spheroids/CTR ** XAV-939

  6. Supplementary S6 - WNT + WNT A B ** * CTR N°spheroids/CTR MF-438 E - WNT C D + WNT ** ** * siCTR N°spheroids/CTR siYAP/TAZ * Viability (A.U.)

  7. Supplementary S7 C A B ** Relative mRNA level Relative mRNA level Relative mRNA level ** * siCTR siCTR siβ-TrcP+siSCD1 siaxin1+siSCD1

  8. Supplementary S8 scd1/taz scd1/yap 1.0 1.0 0.8 0.8 0.6 0.6 Other Other Other Other P=0.024 P=0.013 yap1_low/scd1_low taz_low/scd1_low birc5_low/scd1_low ctgf_low/scd1_low 0.4 0.4 0.2 0.2 0.0 0.0 120 100 80 0 20 60 40 120 100 0 20 40 60 80 OS scd1/birc5 scd1/ctgf 1.0 1.0 0.8 0.8 0.6 0.6 P=0.017 P=0.0004 0.4 0.4 0.2 0.2 0.0 0.0 120 100 120 80 100 0 20 60 80 40 60 0 20 40 MONTHS

  9. Supplementary S9

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