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D48

Selectivity-determining regions. Nonconserved amino acids in the proximity of the PTP active site (yellow) are involved in recognition of PTP substrates and non-peptide PTP inhibitors. SHP specificity region S118. WPD-loop specificity F182. D48. R47. R24. G259.

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D48

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  1. Selectivity-determining regions Nonconserved amino acids in the proximity of the PTP active site (yellow) are involved in recognition of PTP substrates and non-peptide PTP inhibitors SHP specificity region S118 WPD-loop specificity F182 D48 R47 R24 G259 KNRY-loop specificity Second pTyr binding site Areas of conservation (blue – most conserved, red least conserved) represents the Ca-regiovariation score values of 37 aligned human PTP catalytic domains. www.science.novonordisk.com/ptp -Page 5- Andersen et al Mol. Cell. Biol. 2001

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