NORMAL SEXUAL DIFFERENTIATION

1. NORMAL SEXUALDIFFERENTIATION Suganda Tanuwidjaja

2. IDENTITAS GENDER • Genotype • Gonadale Sex • Phenotype Sex • Social Gender

3. GENOTYPE Chromosomal (Genetic) Sex Testis-Determining Genes XY XX Ovary-Determining Genes Gonadale Sex Gonadale Steroids And Peptidas (T.DHT.AMH) (Gonadale Steroids) ♂ ♀ Phenotypic Sex

4. CHROMOSOMAL SEX • Male : 46 XY • Female : 46 XX Y Chromosome (SRY Gene) Diff. of The Bipotential Gonad Testis X Chromosome One Dose Active

6. GONADAL SEX • Gonadal Sex is determined by SRY • Indiff. Gonad (SRY) Ovary (+SRY) Testis

7. 1 X Chromosome : SRY Gonad Ovary (Fetal Periode) Ova Atrophy (Only 1 Chr)

8. STEROID METABOLISM OF GONAD Cholesterol Androgen Enzim Estrogen

9. PHENOTYPE SEX • Internal Ducts • External Genital Appearance • Peran Androgen

10. INTERNAL SEX DUCTS BIPOTENTIAL Masculine Wolffian Ducts Feminine Mullerian Ducts

12. TESTICULAR PEPTIDE PRDCT(SERTOLI CELL) Mullerian Duct Inhibitory Factor (MIF) Mullerian Duct Atrophy Wolffian Duct Developed

13. WITHOUT... MIF Developed : • Uterus • Oviduct • Upper 2/3 of Vagina

14. LEYDIG CELL Testosteron Wolffian Ducts • Epididymis • Vas Deferens • Seminal Vesicle

19. EXTERNAL GENITALIA • Bipotential 8 Weeks • Genital Tubercle Clitoris • Urogenital Fold Labia Minora • Labioscrotal Swelling Labia Majora

21. Testosterone Dihydrotestosterone (DHT) 5α Reductase Enzyme Androgen Receptor (ARs)

22. Penis Genital Tubercle DHT ARs Urogenital Slit Penile Urethra Labioscrotal Fold Scrotum

23. 1st TRIMESTER Maternal Human Chorionic Gonadotropin (hCG) Fetal Testes Testosterone Male Development

24. 2nd TRIMESTER Fetal Pituitary Gonadotropin Testicular Activity Further Normal Growth of The Penis

25. SOCIAL GENDER • Gender Development : 1. Gender Identity 2. Gender Role 3. Sexual Orientation 4. Desire & Capacity for Parenting

26. DETERMINED FACTORS • Surrounding • Physical Differentiation • Interaction • Prenatal Androgen

27. Thank You