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Understanding Peripheral Neuropathy: Causes, Symptoms, and Diagnosis

Peripheral neuropathy refers to nerve damage in the peripheral nervous system. Learn about its classifications, causes, symptoms, and diagnostic procedures. From anatomical to acquired and hereditary origins, discover the diverse factors contributing to this condition. Recognize the signs like weakness, sensory issues, and autonomic dysfunction. Explore diagnostic tests including EMG, nerve conduction studies, and nerve biopsy for accurate identification. Be aware of conditions like Guillain-Barre Syndrome requiring urgent evaluation.

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Understanding Peripheral Neuropathy: Causes, Symptoms, and Diagnosis

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  1. Peripheral neuropathy is the term for damage to nerves of the peripheral nervous system.

  2. classification • Anatomical • Etiological :causes • Pathological • symptomology

  3. Mononeuropathy mononeuropathy multiplex Generalized: polyneuropathy Anatomical

  4. etiological • acquired • VITAMIN D • V:vascuilities, SLE,PAN,.. • I:infection,HIV,CMV,EBV,leprosy • T: truma • A:autimmune • M:Metabolic:DM,vit B12 defciency,hypothyrodism,renal hepatic ,porphyria • I:Infiltrative:sarcidosis, amylodosis • N:Neoplasm: paraneoplastic • D:Demyelinating ,GBS(Guillian barre syndrome or Drugs • Hereditary ,

  5. pathological • Axonal • demyelinating

  6. onset • Acute chronic

  7. Signs and symptoms • Motor :weakness+ lower motor neuron signs • Sensory: +ve or –ve symptoms, gloves and stalk distribution • Autonomic:incotenance, postural hypotention,

  8. Work UP • EMG and nerve coduction study • Look for the causes • LP: protien, glu,WBC (cytoalbumin dissociation)..GBS • ANA,RF,vit B12,TFT,Glu leve,renal,… • Nerve biopsy

  9. GBS • Acute inflamatory demyelinating poly radiculopathy • Preceded by URTI, diarrhea • Asending weaknesss • It is emergency • Diagnosed by EMG ,NCS and LP(cyto albumin dissociation)

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