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VALIDATING AHRQ PATIENT SAFETY INDICATORS with the VA NATIONAL SURGICAL QUALITY IMPROVEMENT PROGRAM POSTOPERATIVE ADVERSE EVENTS. Dennis Tsilimingras, M.D., M.P.H. Center for Health Quality, Outcomes, & Economic Research (Bedford VAMC) Boston University School of Public Health.
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VALIDATING AHRQ PATIENT SAFETY INDICATORS with the VA NATIONAL SURGICAL QUALITY IMPROVEMENT PROGRAM POSTOPERATIVE ADVERSE EVENTS Dennis Tsilimingras, M.D., M.P.H. Center for Health Quality, Outcomes, & Economic Research (Bedford VAMC) Boston University School of Public Health
Co-Investigators • Patrick Romano, M.D., M.P.H.3, William Henderson, Ph.D.4,Peter Rivard, M.H.S.A.1,2,Susan Loveland, M.A.T.1,2,Shibei Zhao, M.P.H.1,2, Cindy Christiansen, Ph.D.1,2,Anne Elixhauser, Ph.D.5,Shukri Khuri, M.D.6, Amy K. Rosen, Ph.D.1,2 • 1Center for Health Quality, Outcomes, & Economic Research (Bedford VAMC) • 2Boston University School of Public Health • 3University of California at Davis • 4NSQIP Denver Data Analysis Center • 5Agency for Healthcare Research and Quality • 6Surgical Service, VA Boston Healthcare System Funding Organization: Department of Veterans Affairs HSR&D Project IIR 02-144-1
Introduction • Patient Safety Indicators (PSIs): - developed by the UC-Stanford and AHRQ collaboration - purpose to screen for potential safety problems using ICD-9-CM codes - limitation: PSIs have not been validated in the past
Research Objectives • To validate the AHRQ PSIs with postoperative adverse events in the VA National Surgical Quality Improvement Program (NSQIP). • To test alternative PSI definitions based on clinical information from NSQIP for the purpose of future refinement of the PSIs.
Methods AHRQNSQIP Accepted PSIs:Postoperative Adverse Events: (1) Postoperative Sepsis (1) Systemic Sepsis (2) Postoperative Respiratory (2) Unplanned Intubation for Failure Respiratory Failure or Failure to Wean from Ventilator > 48hrs (3) Postoperative Pulmonary (3) Deep Vein Thrombosis Embolism or Deep Vein & Pulmonary Embolism Thrombosis (4) Postoperative Wound (4) Dehiscence Dehiscence (5) Postoperative Physiologic (5) Acute Renal Failure and Metabolic Derangements
MethodsStudy Sample • VA administrative inpatient data from the Patient Treatment File (PTF): - from 130 VA hospitals - matched with NSQIP chart-abstracted records - FY 2001 (10/00 – 09/01) from both data sources
Methods • NSQIP: - purpose is to provide reliable, valid, and comparative information regarding morbidity & mortality to all VA medical centers - employs trained nurse data collectors - collects preoperative patient characteristics and 30-day postoperative outcomes
Methods • A hospitalization had a PSI if it met AHRQ’s administrative data definition that includes ICD-9-CM diagnostic and procedure codes. • A hospitalization had a NSQIP event if it met NSQIP’s clinical definition which was translated into ICD-9-CM diagnostic and procedure codes. • Our alternative definition was based on a translation of NSQIP clinical definitions into ICD-9-CM diagnostic & procedure codes.
Methods • Using NSQIP as the “gold standard”: - measured the sensitivity & positive predictive value of “all” 5 AHRQ PSIs - using the current AHRQ PSI definition - compared with the best alternative PSI definition • These definitions were developed using PTF data and validated with NSQIP medical chart-abstracted data.
Postoperative Respiratory Failure ICD-9-CM Definitions Diagnostic codes Procedure Codes AHRQ 518.81 & 518.84 NSQIP 518.5 96.04 & 96.70-96.72 Alternative 518.5, 518.81, & 96.04 & 96.70-96.72 518.84
ResultsSample • 561,436 inpatient hospitalizations (PTF) • 101,548 with surgical Diagnostic Related Groups • 55,752 were matched with NSQIP data, which were used to calculate sensitivities and positive predictive values
Results Sensitivity(%) PPV(%) Current AHRQ PSI Definition 32 44 Alternative PSI Definition (NSQIP) 37 45 Accepted PSIs: (1) Postoperative Sepsis (12,011 hospitalizations) (2) Postoperative Respiratory failure* (24,273 hospitalizations) *PSI includes diagnostic and procedure codes. Sensitivity(%) PPV(%) Current AHRQ PSI Definition 19 74 Alternative PSI Definition (NSQIP) 67 66
Results (3) Postoperative Pulmonary Embolism or Deep Vein Thrombosis* (55,682 hospitalizations) (4) Postoperative Wound Dehiscence* (16,904 hospitalizations) *PSI includes diagnostic and procedure codes. Sensitivity(%) PPV(%) Current AHRQ PSI Definition 56 22 Alternative PSI Definition (NSQIP) 58 22 Sensitivity(%) PPV(%) Current AHRQ PSI Definition 29 72 Alternative PSI Definition (NSQIP) 61 57
Results (5) Postoperative Physiologic and Metabolic Derangements* (27,722 hospitalizations) *PSI includes diagnostic and procedure codes. Sensitivity(%) PPV(%) Current AHRQ PSI Definition 44 54 Alternative PSI Definition (NSQIP) 48 63
Results AHRQ PSI Our Results Best et al 2002 Results† Sens(%)PPV(%) Sens(%)PPV(%) Sepsis 37 45 40 29 Respiratory Failure 67 66 9 52 PE or DVT 58 22 PE 49 48 DVT 12 18 Dehiscence 61 57 25 23 Physiologic & Metabolic Derangements 48 63 16 4 Comparing our results with Best and colleagues. †Best et al. Identifying Patient Preoperative Risk Factors & Postoperative Adverse Events in Administrative Databases: Results from NSQIP. J Am Coll Surg. 2002;194:257-266.
Conclusions • NSQIP clinical data are an excellent source for examining the validity of administrative-data-based indicators, such as the PSIs, as identifiers of potential inpatient surgical patient safety events. • All 5 PSIs were improved by a simple modification to perform better in the VA.
Significance • PSIs may be a useful screening tool for identifying inpatient safety events that warrant further investigation. • Such a tool can be constructed with the incorporation of clinical data definitions to administrative data definitions. • The latest release of the AHRQ PSI software has incorporated certain findings from this study.