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Metabolic syndrome from a gender and cardiovascular perspective

Metabolic syndrome from a gender and cardiovascular perspective. Eva Swahn. IDF Worldwide Definition of the Metabolic Syndrome (2005).

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Metabolic syndrome from a gender and cardiovascular perspective

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  1. Metabolic syndrome from a gender and cardiovascular perspective Eva Swahn

  2. IDF Worldwide Definition of the Metabolic Syndrome (2005) • The metabolic syndrome is a cluster of the most dangerous heart attack risk factors: diabetes and prediabetes, abdominal obesity, high cholesterol and high blood pressure. • A quarter of the world’s adults have metabolic syndrome • Up to 80% of the 200 million people with diabetes globally will die of cardiovascular disease • People with metabolic syndrome are twice as likely to die from, and three times as likely to have a heart attack or stroke compared with people without the syndrome • People with metabolic syndrome have a five-fold greater risk of developing type 2 diabetes

  3. HDL-C TNF IL-6 Insulin AbdominalObesity Glu TG PAI-1 Classical Risk Factors Novel Risk Factors Metabolic syndrome  LDL-C  BP Smoking T2DM Cancer Cardiovascular disease

  4. Abdominal obesity in Stockholm people (60 years old) Waist in cm Women >80 69% Women >88 42% Men >94 64% Men >102 32% Definition Waist in cm Women >80 obs Women >88 action Men >94 obs Men >102 action Prevention of coronary heart disease in clinical practice. Eur Heart Journal 1998;19:1434-1503

  5. Health threat from abdominal obesity is largely due to intra-abdominal obesity Increased Cardiometabolic Risk Abdominal Obesity Dyslipidemia Hypertension Glucose Intolerance Insulin Resistance Intra-Abdominal Adiposity Adapted from Eckel et al 2005

  6. The importance of abdominal obesity on therisk to get myocardial infarction Nurses Health Study, 88 393 women, 34-59 years followed for 20 years, 1980-2000, healthy at study start. Risk to get heart disease Abdominal obesity Overweight Tricia Y.Li et al. Circulation 2006;113:499-506

  7. Copenhagen city heart study EHJ (2002) 23, 620-626

  8. Interheart Food High lipids Diabetes Physical activity Psycosocial factors Alcohol High bloodpressure Overweight Abdominal obesity Smoking Heredity Infection Inflammation Thrombogenic factors coagulation / fibrinolysis Yusuf S et al, Lancet 2004;364:937-52

  9. Moore Less

  10. Energy use kJ/min Levine JA et al. Am J Clin Nutr 2000;72:1451

  11. One cigarette shortens life with 2 min. One beer shortens life with 4 min. One working day shortens life with 8 hours!!!

  12. Thank you for your attention!

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