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Threats to fetal oxygenation during labor– what is the context of your epidural?. Tom Archer, MD, MBA January 31, 2012. The fetus floats at the far end of a tunnel of oxygen delivery. If the tunnel is blocked, the fetus dies.
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Threats to fetal oxygenationduring labor– what is the context of your epidural? Tom Archer, MD, MBA January 31, 2012
The fetus floats at the far end of a tunnel of oxygen delivery. If the tunnel is blocked, the fetus dies. http://darksideofthecatalogue.wordpress.com/2011/11/22/light-at-the-end-of-the-tunnel-is-glowing-thing-23-12/
Systematic approach to thinking about the “risk context” of an epidural • We can do the “usual things” directly related to hypotension more intelligently (fluids, pressors, LUD, O2. • Think about “less usual things” (hyperstimulation, nuchal cord, pre-existing disease that make patient more precarious. • Epidural may only be tangentially “to blame”– or not at all!
The fetal oxygen supply is precarious– both on the fetal and maternal sides of the placental interface med.yale.edu http://www.spiralzoom.com/Science/SpiralsHumanBody/SpiralsHumanBody.html
Fetal-side (umbilical cord) problems with fetal oxygen supply
Nuchal umbilical cord http://library.med.utah.edu/WebPath/PLACHTML/PLAC002.html
Knotted umbilical cord http://library.med.utah.edu/WebPath/PLACHTML/PLAC010.html
Vasa previa– fetal blood vessels between presenting part and cervix– will rupture as presenting part descends. http://midwifemuse.wordpress.com/2008/02/27/vasa-previa/
Prolapsed umbilical cord http://www.empowher.com/media/reference/umbilical-cord-prolapse
Figure 1 Healthy, abundant uteroplacental perfusion Upper body Minimal collateral venous return to heart via lumbar and azygos system Uncompressed aorta and iliac arteries Open IVC Fetal O2 supply
Figure 2 Uterine contractions periodically deprive placenta of perfusion. Upper body Uncompressed aorta and iliac arteries Open IVC Minimal collateral venous return to heart via lumbar and azygos system Fetal O2 supply Uterine contractions
Figure 3 Aortocaval compression reduces placental perfusion pressure. Upper body Increased collateral venous return to heart via lumbar and azygos system Compressed IVC Compressed aorta and iliac arteries ACC Uterine mass ACC Fetal O2 supply Uterine contractions
http://www.manbit.com/OA/f28-1.htm Manbit images
Both positive pressure ventilation and uterine contractions in the presence of free venous return cause the heart to receive periodic increases in venous return. Could these periodic volume challenges shed light on the parturient’s “volume status?” Michard
Figure 4 Placental vascular disease (e.g. preeclampsia) further reduces placental perfusion. Upper body Increased collateral venous return to heart via lumbar and azygos system Compressed IVC Compressed aorta and iliac arteries ACC ACC Uterine mass Fetal O2 supply Uterine contractions Placental vascular disease
Pre-eclampsia: ischemic chorionic villi release pre-E mediators into maternal blood. Say“OUCH!” Pre-E mediators Poor placentation www.siumed.edu/~dking2/erg/images/placenta.jpg
Poor-placentation theory of pre-E: Synciotrophoblast invades myometrium but does not denervate spiral arteries of mother properly. Hence, intervillous flow is sub-optimal. Chorionic villi are ischemic and release mediators (VEGF, etc) which damage maternal endothelium. http://pharyngula.org/images/preeclampsia_model.jpg
Figure 5 Placental abruption reduces placental volume available for gas exchange Upper body Increased collateral venous return to heart via lumbar and azygos system Compressed IVC Compressed aorta and iliac arteries ACC ACC Uterine mass Fetal O2 supply Uterine contractions Placental spiral artery disease Placental abruption or thrombosis
Placental abruption decreases placental area available for gas exchange. http://emedicine.medscape.com/article/252810-overview
Figure 6 Epidural may be “straw that breaks camel’s back” and causes “fetal distress”. Epidural reduces arterial blood pressure Upper body Increased collateral venous return to heart via lumbar and azygos system Compressed IVC Compressed aorta and iliac arteries ACC ACC Uterine mass Fetal O2 supply Uterine contractions Placental vascular disease Placental abruption or thrombosis
“Routine” epidural. http://www.macllp.com/child_birth_anesthesia/epidural_ad.cfm
Your next epidural • Ask yourself, “What are the pre-existing threats to fetal oxygenation in my patient?” • “What special precautions should I take to prevent fetal hypoxia in this patient?” • Be attentive to hyperstimulation, preeclampsia, abruption, hypotension, etc.