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Glutaminase

HO. C=. O. O-PO 3 2-. :. :. NH 3. NH 3. O. - O. C=. O. ADP-O-P-O -. NH 2. - O. O. 2- 3 OP-. C=. O. O-NH 2. Three catalytic domains and a tunnel in the carbamoyl phosphate synthetase. Glutaminase. Carboxy Phosphate Synthetase. Glutamine + H 2 O. Carboxy Phosphate

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Glutaminase

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  1. HO C= O O-PO32- : : NH3 NH3 O -O C= O ADP-O-P-O- NH2 -O O 2-3OP- C= O O-NH2 Three catalytic domains and a tunnel in the carbamoyl phosphate synthetase Glutaminase Carboxy Phosphate Synthetase Glutamine + H2O Carboxy Phosphate (t1/2 = 70 ms) HO C= Glutamate O -O O ADP-O-P-O- Carbamate (t1/2 = 28 ms) -O Carbamoyl Phosphate synthetase + ADP Carbamoyl Phosphate The 3 active sites are separated by 100 A Magenta = glutaminase Green = Carboxy phosphate synthetase Blue = Carbamoyl phosphate synthetase From Curr Opin Struct Biol. 1998 (6):679-85

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