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Mayank A. Nanavaty, DO, MRCOphth, MRCS(Ed) David J. Spalton, FRCP, FRCS, FRCOphth

Randomized Fellow-Eye Controlled Study of Posterior Capsule Opacification with Acrylic Asphereic and Spherical IOL Models. Mayank A. Nanavaty, DO, MRCOphth, MRCS(Ed) David J. Spalton, FRCP, FRCS, FRCOphth James Boyce. PhD. St. Thomas’ Hospital, London.

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Mayank A. Nanavaty, DO, MRCOphth, MRCS(Ed) David J. Spalton, FRCP, FRCS, FRCOphth

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  1. Randomized Fellow-Eye Controlled Study of Posterior Capsule Opacification with Acrylic Asphereic and Spherical IOL Models Mayank A. Nanavaty, DO, MRCOphth, MRCS(Ed) David J. Spalton, FRCP, FRCS, FRCOphth James Boyce. PhD St. Thomas’ Hospital, London DJS & JB were consultants to Alcon Laboratories, Texas, USA. MAN: No financial interests in any product or procedure. This project was supported by grant from Alcon Laboratories MAN: Travel funded by Bausch & Lomb. DJS, JM: No financial interest

  2. Background AcrySof IQ AcrySof Natural The posterior aspheric design of this IOL makes it interesting to study it’s influence on PCO

  3. Aims • To compare post-operative • Visual acuity • Posterior capsular opacification (PCO) • Rhexis area • after implantation of AcrySof IQ and AcrySof Natural IOLs

  4. Methods • Prospective randomised fellow eye comparison • Normal eyes with bilateral cataracts • Single Surgeon, standardised phaco technique • Follow-up at 1m, 3m, 6m, 1yr, 2yrs

  5. Follow-up data At each visit: • 100% & 9% LogMAR BCVA • PCO and rhexis area measured with retroillumination images and POCO software

  6. Results • 94 eyes of 47 patients were enrolled • Average age 76 yrs +/- 7.7 (60-91yrs) • Follow-up at 1m = 94 eyes of 47 patients 3m & 6m = 88 eyes of 44 patients 12m = 84 eyes of 42 patients 24m = 82 eyes of 41 patients • There was no significant difference in capsulorhexis area at any follow up visits between the two groups (p = ns)

  7. Best corrected visual acuity * P=0.03 100% BCVA 9% BCVA p = ns p = ns 1 3 6 Months AcrySof IQ AcrySof Natural

  8. Mean PCO score P < 0.05 at all time points p = ns * * * * * 1 3 6 12 24 Months AcrySof IQ AcrySof Natural

  9. Pt OSP OS AcrySof IQ 1 m 3 m 6 m 1 y 2 y OD AcrySof Natural

  10. Pt ILA OS AcrySof IQ 1 m 3 m 6 m 1 y 2 y OD AcrySof Natural

  11. Optic edge thickness AcrySof IQ AcrySof Natural 197.7 198.7 Not a very big difference in edge thickness! Nanavaty MA, Spalton DJ, et al. J Cataract Refract Surg 2008

  12. Conclusion • Best corrected 100% and 9% LogMAR visual acuity is not different between AcrySof IQ and AcrySof Natural • PCO is not significantly different between the two IOLs at 2 years • Posterior asphericity of AcrySof IQ does not influence the PCO outcomes

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