1 / 12

Effect of CSF pulsations

The Effect of Nerves on Pulsatile CSF Flow and Micro-mixing inside the Human Spinal Canal Nov 18, 2010 Vu Nguyen Supervisor: Ying Hsu Advisor: Andreas A Linninger Laboratory for Product and Process Design (LPPD) University of Illinois at Chicago. Effect of CSF pulsations. t. V. t. V.

martha
Download Presentation

Effect of CSF pulsations

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. The Effect of Nerves on Pulsatile CSF Flow and Micro-mixing inside the Human Spinal CanalNov 18, 2010Vu NguyenSupervisor: Ying Hsu Advisor: Andreas A Linninger Laboratory for Product and Process Design (LPPD)University of Illinois at Chicago

  2. Effect of CSF pulsations t V t V By Dr. Madhawa

  3. Human Spinal Cord Divided into 4 regions: cervical, thoracic, lumbar, and sacral. Diameter of spinal canal and cord varies from the cervical to lumbar region. There are 31 pairs of spinal nerves. Divided into 8 cervical, 12 thoracic, 5 lumbar, 5 sacral, and 1 coccygeal nerve. Do these nerves affect CSF flow in the spinal canal? Zimmer.com 2010 Ko et al. 2004

  4. Goals Study how spinal nerves would affect the pulsatile flow in the subarachnoid space. Study the pressure drop of CSF flow across the spinal canal with and without nerves. Determine whether nerves structures affect the CSF flow.

  5. Construction and Simulation Gambit and Fluent were used to construct the preliminary 2D models for a simple fluid flow. Observations on how different operation conditions affect the model: gravity, diffusivity.

  6. 3D Model of the Spinal Cord Gambit was used to construct the 3D model of the thoracic region of the spinal canal. 1 cm 7.5 cm Injection site 0.5 cm

  7. CSF flow inside Spinal Canal Testing the effect of nerves (flow obstacles) on pressure drop. With Nerves Control

  8. Pressure Gradient with Constant Flow Constant Flow with the speed of 0.5 cm/sec. Pressure Unit: Pascal • Pressure difference: 0.07 Pascal • Conclusion: the existence of nerves increase the pressure difference. ∆P=α*F

  9. Pressure Gradient with Pulsatile Flow Pulsatile Flow simulated by a sinusoidal wave function. Pressure Unit: Pascal. Pressure difference: 0.4 Pascal Conclusion: the existence of nerves increase the pressure drop by approximately 9%.

  10. Pressure drop in pulsatile flow during 1 cycle • Pressure drop in pulsatile flow field fluctuates with the sinusoidal velocity wave • Comparison was made by averaging 1 cycle. • Pressure difference: 0.37891 Pascal. • The previous plots may have overestimated the pressure gradient entering the spinal canal. Average Pressure Drop in Control Model: 3.75 Pascal. Average Pressure Drop in Model with Nerves: 4.13 Pascal

  11. Estimation of Pressure Drop across Entire Human Spine Average Pressure Drop: 4.13 Pascal Average Pressure Drop: 3.75 Pascal 7.5 cm 7.5 cm Spinal cord length: 40-45 cm. Estimated pressure dropfor entire spine 22.5 Pascal Estimated pressure dropfor entire spine 24.8 Pascal By adding nerves in the 3D model of the spine, the pressure drop is increased by 10% over the entire spine. Nerves add significant resistance to CSF flow in the spinal canal. Assumptions: the subarachnoid space is uniform over the entire spine.

  12. References Dafny, Nachum. "Anatomy of the Spinal Cord (Section 2, Chapter 3, Part 1) Neuroscience Online: An Electronic Textbook for the Neurosciences | Department of Neurobiology and Anatomy - The University of Texas Medical School at Houston." Neuroscience Online: An Electronic Textbook for the Neurosciences | Department of Neurobiology and Anatomy - The University of Texas Medical School at Houston. Web. 20 Oct. 2010. <http://neuroscience.uth.tmc.edu/s2/ii3-1.html>. "Spine Anatomy." Zimmer.com. Web. 20 Oct. 2010. <http://www.zimmerspine.eu/z/ctl/op/global/action/1/id/9027/template/PC/navid/9989>. H-Y Ko et al. 2004. Gross quantitative measurements of spinal cord segments in human. International Spinal Cord Society. Vol 42. 35-40. Ikuo Aita et al. 1997. Posterior movement and enlargement of the spinal cord after cervical laminoplasty. The Journal of Bone and Joint Surgery. Vol 80-B. 33-7.

More Related