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Biology 220 Anatomy & Physiology I. Unit I INTRODUCTION. Chapter 1 pp. 1-22 Chapter 27, p. 1005. E. Gorski/ S. Kabrhel. Definitions. Anatomy : Study of structure Macroscopic Anatomy: gross structures, visible to the naked eye Microscopic Anatomy:
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Biology 220 Anatomy & Physiology I Unit IINTRODUCTION Chapter 1 pp. 1-22 Chapter 27, p. 1005 E. Gorski/ S. Kabrhel
Definitions • Anatomy: Study of structure • Macroscopic Anatomy: • gross structures, visible to the naked eye • Microscopic Anatomy: • small structures not visible to the naked eye • Histology (tissues) • Cytology (cellular anatomy) • Physiology: Study of functions at system, organ, tissue, cellular or molecular level REMEMBER: Function follows form Give examples of structures and their functions
Levels of Structural Organization See Fig. 1.1, p. 3 Chemical:Atoms & Molecules (proteins, carbohydrates, nucleic acids, lipids) Cell: Smallest unit of life; Organelles (cellular structures with specific functions) Tissue: Similar cells grouped together to perform a function; • 4 major types: epithelial tissues; muscle tissues; connective tissue; nervous tissue Organ: Two or more types of tissues working together to perform a specific function System:= Organ System; Organs working together to perform an overall function Organism:Made up of many organ systems
Student activity • Name the human organ systems and list the organs of each.
Characteristics of Life • Organization (cell membrane, organelles, skin) • Metabolism (chemical reactions) • Responsiveness (recognize changes in environment and creates responses) • Growth (increase in size) • Development (the changes an organism undergoes from fertilization until death) • Reproduction (cellular or organism)
Homeostasis • Maintenance of body’s internal environment within specific ranges • Homeostatic imbalance - occurs when homeostatic mechanisms fail • Control of homeostasis – prevents extreme deviations by feedback mechanisms • accomplished by nervous and endocrine systems See Fig. 1.4, p. 9
Components of Control System • Receptor(sensor)-sends information to • Control center- receives and analyzes input, and determines output; sends information along efferent pathway to • Effector- output=response
Control Systems of Homeostasis • Feedback mechanisms: • body recognizes deviation and creates response • Negative feedback • response counteracts deviation • Positive feedback • response intensifies deviation
Negative Feedback • response counter-acts (decreases or increases) deviation until normal range is attained • most body functions are controlled with negative feedback • example: control of blood pressure see Fig. 1.5, p. 11 Give other examples of negative feedback. see Fig. 1.6, p. 11
Positive Feedback • response intensifies deviation until major event happens • see Fig. 1.8, p. 12 • Examples: • platelet plug formation and blood clotting • release of milk during lactation • contractions during labor (childbirth) • action potential in neurons
Let’s apply: Harmful Positive Feedback • Extreme blood loss blood pressure decreases/increases? blood flow to heart decreases/increases? heart pumps more/less blood? it causes blood pressure decrease/increase? the heart stops pumping death See Fig. 1.9, p. 12
Let’s apply: Student Activity • A small family was traveling in its van and had a minor accident. The children in the back seats were wearing lap belts, but still sustained numerous bruises about the abdomen, and had some internal organ injuries. • Why is this area more vulnerable to damage than others?
Interstitial Fluid (between tissue cells) (~80% = 12 L) Plasma (outside blood cells) (~20% = 3 L) Body Fluids and Compartments • Intracellular Fluid (ICF) • Inside cells (25 L) • ~ 40% of body weight • (~2/3 of total fluid) • Extracellular Fluid (ECF) • Outside cells (15 L) • 20% of body weight • (~1/3 of total fluid) See Chapter 27, p. 1005
Body Fluids and Compartments ICF and ECF are different in composition • ICF - higher in potassium (K+), phosphate (HPO4=), protein • ECF - higher in chloride (Cl-), sodium (Na+) See Chapter 27, p. 1005
Review: The Language of Anatomy • Anatomical Position and Directional Terms* see Fig 1.10, p. 13 • Regional Terms* see Fig 1.11, p.15 • Abdominopelvic Regions and Quadrants* see Fig 1. 12, p. 16 • Body Planes and Sections* see Fig. 1.13, p.17 see Fig. 1.14, p. 18 *Will also be covered in laboratory
Review: The Language of Anatomy • Body Cavities* • Dorsal Body Cavity (brain and spinal cord) • Ventral Body Cavity (other internal organs) • Other Body Cavities (e.g., nasal, oral cavity) see Fig. 1.15, p. 18 *Will also be covered in laboratory
Let’s Apply • Exposure to a hot environment causes the body to sweat. The hotter the environment, the greater the sweating. Two A&P students are arguing about the mechanism involved: • Student A claims that it is a positive feedback • Student B claims that it is a negative feedback • Who is right? Explain why?
General Biology Review • NOTE: The slides on General Biology Review are provided for student’s reference. This section will NOT be included in the first lecture unit exam. Chapter 2, pp. 23-54; see also Sackheim
General Biology Review:Composition of Matter • Atoms: • Nucleus: Protons (+) and Neutrons • Electrons (-) • Ions: • Cations (+); Anions (-) • Molecule – combination of two or more atoms of the same element, e.g., O2 • Compound – combination of two or more different kinds of atoms, e.g., H2O • Electrolytes – substances that conduct electrical current in solution.
General Biology Review:Bonding • Ionic - between cations and anions • e.g., Na+ + Cl- (sodium chloride) • Covalent - shared electrons • nonpolar covalent (even sharing) • polar covalent (uneven sharing) • Hydrogen bonding - weak attraction • common between water molecules (surface tension)
General Biology Review:Acid/Base Balance pH = measure of the amount of H+ in solution = -log [H+]; • neutral = pH 7 = 10-7 moles H+/liter • Acids- donate H+ lower pH • e.g., H2CO3H+ + HCO3- • Bases- donate OH-or accept H+ raise pH • e.g., KOH K+ + OH- • Acids or Bases may be inorganic (e.g., HCl, KOH) or organic (e.g., H2CO3)
General Biology Review:Acid/Base Balance • Strength and Concentration • Strength = ability to dissociate (ionize) • inorganic acids/bases are usually strong • organic acids/bases are usually weak • Concentration = amount of solute in solution • Buffers • help prevent radical changes in pH • replace strong acid/base with weaker one
General Biology Review:Organic Compounds Carbohydrates Lipids Nucleic Acids Proteins General Functions: Structure Catalysts Transportation Movement pH and Osmoregulation Regulation Defense Against Diseases