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Q: How can we prevent or treat Alzheimer’s Disease?

Explore methods to prevent Alzheimer's disease progression with plaque degraders and promote neuron regeneration. Design a device for accurate preterm labor detection using fetal fibronectin indicators.

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Q: How can we prevent or treat Alzheimer’s Disease?

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  1. Q: How can we prevent or treat Alzheimer’s Disease?

  2. Prevent progression of AD by creating devices that generate plaque degraders (fibril deposits) Amyloid beta-peptides Neurofibrilly tangles Protein that degrades tangles and deposits Device

  3. One way to treat AD is to regenerate neurons

  4. Salamanders can regenerate limbs, including all motor neurons, muscle and blood vessels. • look for the genes that specifically aim to regenerate motor neurons. • Create a device that contains a part that includes salamander regeneration gene(s) to promote neuron regeneration in the brain http://www.cellscience.com/reviews2/Organ_Regeneration_Immune_Involvement.html

  5. Q: Can we design an accurate indicator for preterm labor? • Screening for preterm labor is the first step in the process of preventing preterm birth • Fetal Fibronectin (fFN) in vaginal secretions can really only accurately say if patient is NOT in labor • Need an accurate method to detect preterm labor and prevent it

  6. Fetal Fibronectin Dilation of Cervix http://www.mydr.com.au/files/images/categories/pregnancy/cervix.jpg http://www.ffntest.com/info/fetal_test/what_fetal.html fFN is a glue-like protein that holds the fetal membrane and maternal membrane together. It is released and found present in vaginal secretions closer to labor. • Dilation of the cervix is another symptom of labor. • Oxytocin is responsible for contractions

  7. INPUT OUTPUT High Levels of fFN Decrease in Progesterone Increase in Oxytocin Cervical Dilation Banana Smell (MIT iGEM 2006) Progesterone (to suppress contractions) Device Goal: To create a device to implant in the vagina that senses four symptoms of labor and expresses an aromatic gene as an indicator of preterm birth.

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