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Global Prevention and Treatment of Pediatric HIV-1 Infection

Global Prevention and Treatment of Pediatric HIV-1 Infection. Katherine Luzuriaga, M.D. Professor Pediatrics & Molecular Medicine UMMS. Pediatric HIV/AIDS: 2005. 2.5 million infants at risk for MTCT. 620,000 newly infected per year.

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Global Prevention and Treatment of Pediatric HIV-1 Infection

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  1. Global Prevention and Treatment of Pediatric HIV-1 Infection Katherine Luzuriaga, M.D. Professor Pediatrics & Molecular Medicine UMMS

  2. Pediatric HIV/AIDS: 2005 • 2.5 million infants at risk for MTCT. • 620,000 newly infected per year. • Industrialized countries: ART have markedly decreased MTCT and pediatric HIV-related morbidity and mortality. • Resource limited settings: Simplified ART regimens can prevent MTCT but implementation has been difficult; half of HIV infected children die by their second birthday.

  3. International Clinical Trials Prevention of MTCT: PACTG: Phase I-III Nevirapine Trials South Africa: South African Intrapartum Nevirapine Trial IMPAACT: International Pediatric Adolescent and Adult AIDS Clinical Trials Group Pediatric Treatment: Cambodia: Modified DOT Trial in Children • Dr. Sam Sophan, National Pediatric Hospital, Phnom Penh IMPAACT

  4. Pediatric HIV-1 Vaccine: Rationale • ART efficacy will be limited by cost, logistical issues, and the emergence of resistance. • Neonatal immunization may not only protect against perinatal and breast milk HIV-1 transmission, but may also form the basis for lifetime immunity. • Neonatal immunizations utilize existing infrastructure for delivery of childhood vaccines.

  5. MVA/Fowlpox Vaccine Milestones

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