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Understanding Rabies Virus and its Transmission

Explore the characteristics, transmission modes, and symptoms of the rabies virus in this comprehensive guide. Learn about the incubation period in humans, clinical manifestations, and the potential for prevention through post-exposure vaccination.

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Understanding Rabies Virus and its Transmission

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  1. Rhabdoviruse familyRhabdo ( Rod)Rabies virus

  2. Rabies • Acute CNS infection of warm-blooded animals. (Dogs, cats, wolfes, foxes, cattles, bats)

  3. Rabies virus BULLET-SHAPED (1 flat end and 1 round end) ss RNA NON SEGMENTED ENVELOPED 1 serotype & 2 biotypes (street & Fixed)

  4. Rabies Virus

  5. Moods of transmission • Bite of rabid animal(Zoonotic) through infected saliva. Virus migrates up peripheral nerves to the spinal cord and ends in the brain with no viraemia<<<< the salivary glands(Saliva) & the cornea • Non bite transmission • Aerosol transmission from bats. • Organ donations: in 2004, 4 cases in USA documented from corneal transplantation. • Contamination of an open wound or a mucous membrane

  6. Incubation of Rabies • Averages 2 - 16 weeks • Can be as short as 1 week or up to 1 year • The two most important factors in incubation of the virus are • Bite location & severity & • amount of the viruses

  7. In Humans • fever, headache, and general weakness or discomfort. • insomnia, anxiety, confusion, slight or partial paralysis, excitation, hallucinations, hypersalivation difficulty in swallowing, and hydrophopia (fear of water). • Convulsions, paralysis, coma, Death.

  8. In unvaccinated humans, rabies is almost always fatal after neurological symptoms have developed, But ????? rapid post-exposure vaccination may prevent the virus from progressing

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