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Lara Vojnov, PhD Department of Pathology and Laboratory Medicine University of Wisconsin-Madison

The majority of freshly sorted SIV-specific CD8 + T cells cannot suppress viral replication in SIV-infected macrophages. Lara Vojnov, PhD Department of Pathology and Laboratory Medicine University of Wisconsin-Madison Madison, WI, USA. Evidence of HIV/SIV infection of macrophages.

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Lara Vojnov, PhD Department of Pathology and Laboratory Medicine University of Wisconsin-Madison

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  1. The majority of freshly sorted SIV-specific CD8+ T cells cannot suppress viral replication in SIV-infected macrophages • Lara Vojnov, PhD • Department of Pathology and Laboratory Medicine • University of Wisconsin-Madison • Madison, WI, USA

  2. Evidence of HIV/SIV infection of macrophages In vivo SIVmac239 infection of macrophages in intestinal lymphoid nodule CD68+ macrophages comprise 10% of the SIVmac251 cell population in vivo Veazey et al. Science 1998 Zhang et al. Science 1999

  3. Evidence of HIV/SIV infection of macrophages PNAS 2001 Veazey et al. Science 1998 Zhang et al. Science 1999

  4. SAMHD1 inhibits HIV infection of macrophages without Vpx

  5. Hypothesis Macrophages play an important role in HIV/SIV infection as a viral reservoir resistant to CTL-mediated lysis.

  6. SIV-specific CD8+ T cells suppress viral replication in SIV-infected CD4+ T cells MHC matched infected targets MHC mismatched infected targets

  7. SIV-specific CD8+ T cells poorly suppress viral replication in SIV-infected macrophages MHC matched infected targets MHC mismatched infected targets

  8. CD4+ T cells vs macrophages

  9. SIV-specific CD8+ T cells poorly suppress viral replication in SIV-infected macrophages 32% 88%

  10. SIV-specific CD8+ T cells poorly suppress viral replication in SIV-infected macrophages 30% 3%

  11. Bulk CD8+ T cells suppress viral replication in SIV-infected CD4+ T cells

  12. Bulk CD8+ T cells poorly suppress viral replication in SIV-infected macrophages

  13. Time-course of SIV-infected elite controllers

  14. Acknowledgements National Institutes of Health Jorge Almeida Danny Douek NEPRC R. Paul Johnson FIOCRUZ – Rio De Janeiro Myrna Bonaldo Marlon Veloso de Santana Patricia Costa Neves Ricardo Galler University of Wisconsin-Madison Mauricio Martins Alexander Bean Jonah Sacha Holly Kolar Nancy Wilson Benjamin Burwitz David O’Connor University of Miami David Watkins Ann Dauphin Mario Stevenson

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