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Estimation of placenta function using T 2* measurements during hyper- and normoxia

Mother w/o mask. Mother + O 2 mask. Estimation of placenta function using T 2* measurements during hyper- and normoxia. 0 . 10 . 2 0 . 30 . 40 . 50 . 6 0 . 70 . 8 0 . 90 . 100 . 4142. May 9 th , 12 am, Computer no 73. David Alberg Peters

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Estimation of placenta function using T 2* measurements during hyper- and normoxia

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  1. Mother w/o mask Mother + O2 mask Estimation of placenta function using T2*measurements during hyper- and normoxia 0 10 20 30 40 50 60 70 80 90 100 4142 May 9th, 12 am, Computer no 73

  2. David AlbergPeters • Department of Clinical Engineering, Central Denmark Region, Aarhus, Denmark • David.Peters@stab.rm.dk • Anne Sørensen • Department of Obstetrics and Gynecology, Aarhus University, Aalborg Hospital, Denmark • TorbenFründ • Department of Radiology, Aarhus University, Aalborg Hospital, Denmark • Ole BjarneChristiansen • Department of Obstetrics and Gynecology, Aarhus University, Aalborg Hospital, Denmark • NielsUldbjerg • Department of Obstetrics and Gynecology, Aarhus University Hospital, Denmark. Estimation of placenta function using T2*measurements during hyper- and normoxia 4142 May 9th, 12 am, Computer no 73

  3. Materials 6 x g.w. 28-35 MATLAB

  4. Protocol • Bold imaging (separate study) • Multi Echo GE • Multi Echo GE Localizer 10 min Normoxia (21% O2) Hyperoxia (100% O2) • Multi Echo GE • TR=70.9ms, TE=3.02 to 67.5 ms – step 4.3 ms. • FOV 350x350 mm, Matrix 256 x 128, Three 8 mm slices

  5. Acquisition Placenta ROI Multi Echo GE sequence - Increasing TE

  6. Processing • T2* fitted (Levenberg Marquardt implemented in MATLAB) • Fitted either Pixel by pixel or in a region of interest (ROI)

  7. Results (ROI based fitting) Subject 1 Subject 2 Mean change (P<0.01) Subject 3 Subject 4-5-6

  8. Results (Pixel by pixel fitting) Normoxic Hyperoxic T2* (ms) 0 10 20 30 40 50 60 70 80 90 100

  9. Conclusion • T2* increases significantly in the placenta when the mother breathes oxygen • The change in T2*is inhomogeneously distributed in the placenta • The change in T2* is most likely caused by a change in the pO2 of the blood in placenta

  10. Placenta structure Fetal placenta Maternal placenta

  11. Discussion Same? Same? Correspondance between “blue” areas in pre oxygen T2* map and fetal side of placenta?

  12. Discussion • Is the difference between hyperoxic and normoxic placenta T2* value an indicator of placenta function? • Is a reduced response sign of a poorly functioning placenta?

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