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AFP Journal Review September 15, 2007 Issue

Articles Featured. Gout: An UpdateMetatarsal FracturesOcular EmergenciesLateral Epicondylitis. Gout: An Update. Gouty Arthritis accounted for 3.9 million outpatient visits in U.S in 2002.Prevalence is increasing due to aging, obesity and diuretic treated HTN.Often under diagnosed and under trea

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AFP Journal Review September 15, 2007 Issue

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    1. AFP Journal Review September 15, 2007 Issue Marzena Slater, M.D. PGY-2 Emory Family Medicine

    2. Articles Featured Gout: An Update Metatarsal Fractures Ocular Emergencies Lateral Epicondylitis

    3. Gout: An Update Gouty Arthritis accounted for 3.9 million outpatient visits in U.S in 2002. Prevalence is increasing due to aging, obesity and diuretic treated HTN. Often under diagnosed and under treated Questionable association of gout and MI in men.

    4. Gout: Pathophysiology Uric acid a metabolic bi-product of purine catabolism In humans and great apes uricase is mutated Hyperuricemia (>6.5 mg/dL) is caused by high purine diet combined with alcohol use, diuretics, and reduced renal clearance Monosodium urate crystals deposit in tissues leading to: Arthritis Soft tissue masses (tophi) Nephrolithiasis Urate Nephropathy

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