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The coolness of shape!!!

The coolness of shape!!!. Why do we care to care???. DNA and PCB = flat. Sickle cell anemia. Beta chain #6 amino acid normal = glutamine (a polar amino acid) Mutation = valine (non-polar) = sickle cell Caused by 1 single “letter” change in the DNA. More sickle cell. Good against malaria.

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The coolness of shape!!!

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  1. The coolness of shape!!! Why do we care to care???

  2. DNA and PCB = flat

  3. Sickle cell anemia • Beta chain #6 amino acid • normal = glutamine (a polar amino acid) • Mutation = valine (non-polar) = sickle cell • Caused by 1 single “letter” change in the DNA

  4. More sickle cell

  5. Good against malaria • People of Africa descent are common carriers (heterozygous) for sickle cell (1/2 of their blood is sickle cell • Because the “sharp, spear like shape” can puncture the protozoa (plasmodium genius) that causes malaria and kill em!!!! • Environment huge factor for diseases! • Coolness • yarp

  6. More on hemoglobin • Why don’t you draw out: and electron dot Pac man hemoglobins (don’t forget about baby Hb) How oxygen, carbon dioxide, and carbon monoxide bind

  7. Nerdy poisons • Hydrogen cyanide = deadly poison • Do electron dot. • Binds to cytochromeoxidase the same as carbon monoxide binds to hemoglobin • Who cares??? • This is the very end of the conveyer belt of electron transport chain (glycolysis) where oxygen is needed. • Completely stops/backs up metabolism of glucose, the only source of energy for the brain.. Brain death… • yarp

  8. Last nerdy poison • Arsenic slows down glycolysis as well… • H3AsO4 stops one of the 2 formations of pyruvate… cuts in half the amount of energy. • Can build “tolerance”

  9. others • Caffeine and ADH • DNA dyes • Lots of stuff!!!! • Nerdy!!!! • yarp

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