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What is the relationship between near infrared spectroscopic regional mixed arterio-venous oxygen saturation and jugular bulb venous saturation during core cooling and bilateral selective antegrade cerebral perfusion?.
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What is the relationship between near infrared spectroscopic regional mixed arterio-venous oxygen saturation and jugular bulb venous saturation during core cooling and bilateral selective antegrade cerebral perfusion? Vamsidhar B Dronavalli, Ashvini Menon, Ishtiaq Rahman, David Green, Timothy Jones, Jorge Mascaro, Robert S Bonser Department of Cardiothoracic Surgery, University Hospital Birmingham NHS Foundation Trust, Queen Elizabeth Hospital, Birmingham, UK. Conflict of interest - none
Aim • To assess near infrared spectroscopy (NIRS) as a regional index of mixed arterio-venous cortical saturation (rSO2 ) in managing patients during core cooling (CC)
Introduction Increasing jugular bulb venous oxygen saturation(SjO2) during CC correlates with reducing brain O2 consumption and guides safe commencement of hypothermic circulatory arrest (HCA). NIRS a regional index of rSO2 has been advocated as a surrogate of SjO2.
Methodology • 9 patients undergoing CC • Utilising NIRS, rSO2 was measured • At 35oC, 30oC, 25oC and 15oC during CC • At 5, 15 ,30 and 45 mins of SACP • At 15oC, 20oC, 25oC ,30oC and 35oC during warming • Utilising a jugular bulb line venous oxygen saturation, SjO2 was measured at similar time points • Standardised anaesthetic and bypass protocol
The patients 15 patients 5x Ascending aortic aneurysm and arch aneurysm 2x Mega aortic syndrome 1X chronic type A dissection 1x Pseudo aneurysm of distal arch and proximal descending Mean age=55 Diagnosis 7x Ascending aorta + arch + elephant trunk ± Aortic valve replacement 2x Ascending aorta+ arch replacement Procedures
Results Both rSO2 and SjO2 increased with cooling p<0.01 and p=0.03 repectively
Conclusion NIRS rSO2 assessment during CC underestimates SjO2 for reasons that remain unclear. Regional SO2 is paradoxically lower than SjO2 during CC and our data raises questions of what each index of oxygen extraction is actually measuring.