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Bromocriptine QR

Explore how Bromocriptine QR regulates the biologic clock and insulin resistance syndrome, offering insights into adaptive and maladaptive responses. Learn about the proposed mechanisms of action, benefits, and outcomes when combined with other OHAs.

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Bromocriptine QR

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  1. Bromocriptine QR The Biologic Clock

  2. Modern Insulin Resistant Man “Locked” IntoSeasonal Insulin Resistance Syndrome Physiology (Neuroendocrinology; Winter Condition All Year Long) Insulin resistance begets insulin resistance: hyperinsulinemia in hypothalamus reduces nutrient sensing via increased NE/5HT, overcoming normal spring rise in dopa/decreasing dopa in spring ADAPTIVE Insulin Resistance MAL-ADAPTIVE Insulin Resistance Cincotta AH. et al. Taylor and Francis, Eds Hansen, B Shafrir, E London. 2002. 271-312. Meier AH, Cincotta AH et al. Diabetes Reviews. 1996. 4(4):464-86.

  3. The Biologic Clock Integrator of Signals Uses DOPAMINE SCN Summer Winter Low Dopa Set PM-Winter High IR High Sympathetic tone Persistent High Dopa Set AM-Summer Low IR Low Sympathetic tone Maladaptive Hyperglycemia, high fat/sugar diets, altered sleep/wake cycles, no exercise, stress patients with genetically susceptible b-cell Diabetes Mellitus Afferent signals to SCN that maintain low dopa set include 1. persistent hyperglycemia, 2. high fat/ high sugar diet, 3. no exercise 4. altered sleep/ wake cycle, 5. stress

  4. Bromocriptine QR: Proposed mechanism of action Morning administration (within 2 hours of waking) of AGENT Low dopaminergic tone in hypothalamus in early morning in diabetes Restoration of morning peak in dopaminergic activity (via D2 receptor-mediated activity) Corrects • Sympathetic tone • HPA axis tone  Hepatic gluconeogenesis  FFA and TG  Insulin resistance  Inflammation/hypercoagulation • Sympathetic tone • HPA axis tone  Hepatic gluconeogenesis  FFA and TG  Insulin resistance  Inflammation/hypercoagulation Decreased postprandial glucose levels Reduction in insulin resistance Day-long reduction in plasma glucose, TGs and FFAs Impaired glucose metabolism, hyperglycemia and insulin resistance Adverse cardiovascular pathology Fonseca. Use of Dopamine agonists in Type-2-Diabetes. Oxford American Pocket Cards. OUP, 2010 Cincotta. Hypothalamic role in Insulin Resistance and insulin Resistance Syndrome. Frontiers in Animal Diabetes Research Series. Taylor and Francis, Eds Hansen, B Shafrir, E London, pp 271-312, 2002

  5. Bromocriptine Effect on HbA1c in Combination with other OHAs

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