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Bromocriptine QR

Bromocriptine QR. The Biologic Clock. Modern Insulin Resistant Man “ Locked ” Into Seasonal Insulin Resistance Syndrome Physiology (Neuroendocrinology; Winter Condition All Year Long).

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Bromocriptine QR

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  1. Bromocriptine QR The Biologic Clock

  2. Modern Insulin Resistant Man “Locked” IntoSeasonal Insulin Resistance Syndrome Physiology (Neuroendocrinology; Winter Condition All Year Long) Insulin resistance begets insulin resistance: hyperinsulinemia in hypothalamus reduces nutrient sensing via increased NE/5HT, overcoming normal spring rise in dopa/decreasing dopa in spring ADAPTIVE Insulin Resistance MAL-ADAPTIVE Insulin Resistance Cincotta AH. et al. Taylor and Francis, Eds Hansen, B Shafrir, E London. 2002. 271-312. Meier AH, Cincotta AH et al. Diabetes Reviews. 1996. 4(4):464-86.

  3. The Biologic Clock Integrator of Signals Uses DOPAMINE SCN Summer Winter Low Dopa Set PM-Winter High IR High Sympathetic tone Persistent High Dopa Set AM-Summer Low IR Low Sympathetic tone Maladaptive Hyperglycemia, high fat/sugar diets, altered sleep/wake cycles, no exercise, stress patients with genetically susceptible b-cell Diabetes Mellitus Afferent signals to SCN that maintain low dopa set include 1. persistent hyperglycemia, 2. high fat/ high sugar diet, 3. no exercise 4. altered sleep/ wake cycle, 5. stress

  4. Bromocriptine QR: Proposed mechanism of action Morning administration (within 2 hours of waking) of AGENT Low dopaminergic tone in hypothalamus in early morning in diabetes Restoration of morning peak in dopaminergic activity (via D2 receptor-mediated activity) Corrects • Sympathetic tone • HPA axis tone  Hepatic gluconeogenesis  FFA and TG  Insulin resistance  Inflammation/hypercoagulation • Sympathetic tone • HPA axis tone  Hepatic gluconeogenesis  FFA and TG  Insulin resistance  Inflammation/hypercoagulation Decreased postprandial glucose levels Reduction in insulin resistance Day-long reduction in plasma glucose, TGs and FFAs Impaired glucose metabolism, hyperglycemia and insulin resistance Adverse cardiovascular pathology Fonseca. Use of Dopamine agonists in Type-2-Diabetes. Oxford American Pocket Cards. OUP, 2010 Cincotta. Hypothalamic role in Insulin Resistance and insulin Resistance Syndrome. Frontiers in Animal Diabetes Research Series. Taylor and Francis, Eds Hansen, B Shafrir, E London, pp 271-312, 2002

  5. Bromocriptine Effect on HbA1c in Combination with other OHAs

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