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Synchrotron Radiation for Macromolecular Crystallography

This report by the Office of Science and Technology Policy highlights the significance of synchrotron radiation for macromolecular crystallography. The working group emphasizes boosting operational support for biologists, enhancing equipment, facilitating R&D, refining access procedures, and expanding crystallographic capabilities. Recommendations aim to improve staffing, upgrade detectors, streamline operations, and meet the growing demand for synchrotron access in structural biology.

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Synchrotron Radiation for Macromolecular Crystallography

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  1. Synchrotron Radiation for Macromolecular Crystallography Report of the Office of Science and Technology Policy Working Group on Structural Biology at Synchrotron Radiation Facilities January 1999

  2. Working Group Members Marvin Cassman, Ph.D. (Chair) Director National Institute of General Medical Sciences National Institutes of Health Mary Clutter, Ph.D. Assistant Director for Biological Sciences National Science Foundation Patricia Dehmer, Ph.D. Associate Director of Energy Research Office of Basic Energy Sciences Office of Energy Research Department of Energy Beverly Hartline, Ph.D. Assistant Director for Physical Sciences and Engineering Office of Science and Technology Policy Executive Office of the President Ari Patrinos, Ph.D. Associate Director Office of Biological and Environmental Research Department of Energy John J. Rush, Ph.D. Leader, Neutron Condensed Matter Science Group Center for Neutron Research National Institute of Standards and Technology Judith Vaitukaitis, M.D. Director National Center for Research Resources National Institutes of Health

  3. “Report of the Basic Energy Sciences Advisory Committee Panel on DOE Synchrotron Radiation Sources and Science”, November 1997. “Structural Biology and Synchrotron Radiation Evaluation of Resources and Needs”, Structural Biology Synchrotron Users Organization, December, 1997. “Survey of Structural Biology Beam Lines and Instrumentation at US Synchrotron Centers — Needs and Opportunities for the Future”, Keith Hodgson and Eaton Lattman, February, 1998. “Report of the Structural Biology Subcommittee of the Biological and Environmental Research Advisory Committee”, July, 1998.

  4. Demand for access to synchrotrons to carry out x-ray crystallographic studies of biological macromolecules is increasing rapidly.

  5. Although biologists are increasingly heavy users, operational support comes largely from physics and material sciences at DOE and NSF.

  6. Improve staffing levels at existing beamlines.

  7. Upgrade detectors and other equipment.

  8. Continue efforts to support R&D.

  9. Improved access procedures.

  10. Upgrade of facility operations.

  11. Expansions of existing crystallographic capabilities.

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