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DBS on Parkinson’s Disease

DBS on Parkinson’s Disease. By: Christopher Ross DeSanto BME 181 / February 11, 2010. What is Parkinson’s Disease ?. Parkinson’s Disease. Neuro-degenerative Disorder Dopamine Deficiency Causes emotional and physical complications Affects Substantia Nigra. Parkinson’s. of. Physiology.

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DBS on Parkinson’s Disease

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  1. DBS on Parkinson’s Disease • By: Christopher Ross DeSanto • BME 181 / February 11, 2010

  2. What is Parkinson’s Disease ?

  3. Parkinson’s Disease • Neuro-degenerative Disorder • Dopamine Deficiency • Causes emotional and physical complications • Affects Substantia Nigra

  4. Parkinson’s of Physiology

  5. Current Treatments of Parkinson’s

  6. No cure for Parkinson’s • Most Parkinson’s patients are on a drug regimen • Parkinson’s Disease medication target symptoms only • No medication ensures life-long stability • Most common drug today is Levodopa

  7. Levodopa is converted into dopamine • Does not produce dopamine receptive cells • Does not stimulate cells to take in dopamine • DBS is an alternative to Levodopa

  8. Deep Brain Stimulation

  9. What is DBS? • A Deep Brain Stimulator is a device called a brain pace maker that is implanted into the brain. • Connected to an IPG (implanted pulse generator) • Sends electric pulses to the brain that stimulate dopamine production • Placed on the VIM of the brain

  10. DBS • A reversible procedure • Requires skull penetration • Nodes placed directly on brain (lead) • Lead carries the charge

  11. Statistics • 80% of patients experience little to no tremors after DBS use • For some patients medication is still needed but for all it reduces dosage needed • DBS has been reported to work for 4 to 6 years. • Everyone responds differently • Known to cause loss of feeling in face or limbs

  12. How DBS Came To Be

  13. Cures for Parkinson’s began in 1909 • Involved dangerous lesions to the brain (lobotomies) • 1947 created Stereo- encephalotome • Placed electric nodes over VIM section of brain • VIM still utilized today against Parkinson’s with DBS

  14. Modern DBS Technology

  15. Modern Applications of DBS • New technology being made yearly • Recently: RLS treatments • Sleep Disorder cure • Significant data has been found that it works better with those acute/ severe symptoms

  16. Where I see DBS going ...

  17. Questions?

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