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50. Density of Reactive Astrocytes (GFAP-positive cell/4x10 3 m m 2 ). 40. 30. 20. 300. 250. GFAP intensity of Astrocytic Soma (Arbitrary Units). 250. 200. 200. Neurons (Cells / 4 X10 3 m m 2 ). 150. 150. 100. 50. 1000. Size of the astrocytic soma (Arbitrary Units).

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  1. 50 Density of Reactive Astrocytes (GFAP-positive cell/4x103mm2) 40 30 20 300 250 GFAP intensity of Astrocytic Soma (Arbitrary Units) 250 200 200 Neurons (Cells / 4 X10 3mm2) 150 150 100 50 1000 Size of the astrocytic soma (Arbitrary Units) CuCl2 - + + + + 600 APP135-156(mM)-- 1.0 2.5 5.0 200 CuCl2 - + + + + APP135-156(mM)-- 1.0 2.5 5.0 A B E * * C D F * G * * H * *

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