Research Plans Computational Neuroscience

1. Research Plans Computational Neuroscience • Jutta Kretzberg • University of Antwerp • 7.6.2007 • http://www.uni-oldenburg.de/sinnesphysiologie/en/

2. time Central question: Neural coding • Important response features • Individual cells • Cell ensembles • Origin of neuronal responses • Cellular properties • Network interactions • Reliability of responses

3. Leech nervous system Currently used systems Vertebrate retina

4. Retinal coding - current projects • Latency-based retinal coding of visual stimuli during eye movements • Retinal ensemble coding under dynamic conditions • Mechanisms of retinal coding for global image movement Multi-electrode recordings and data analysis (Bayesian reconstruction, metric-based clustering, information-theoretic methods)

5. Horizontal cell physiology Kolb 1974 Retinal coding - future projects Retinal network interactions Simulations based on physiological data (networks of simplified models, multi-compartment models)

6. Experiment Simulation Leech CNS - current project Influence of ion channel distribution on spike activity 200 Electrophysiology and Simulations (intracellular recordings, multi-compartment models)

7. Leech CNS - future projects Local bend network • Encoding of touch stimuli • Interaction of inputs to interneurons • Sources of variability • Network interactions between sensor cells • Role of electrical connections in the network Electrophysiology and Simulations (intracellular recordings, multi-compartment & network models)

8. Common interests with TNB group

9. New impulses • Sensory coding • Well-defined input and output • Direct link to behavior • Analysis of retinal network • Multi-electrode recordings • Several data analysis methods • Analysis of leech network • Easily approachable microcircuit • Close sensory-motor interaction Similar questions and methods: Comparison of different systems